Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests

NCT ID: NCT04125134

Last Updated: 2025-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-03

Study Completion Date

2025-07-31

Brief Summary

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This is a single site, prospective, cross-sectional, controlled clinical study on a total of 66 subjects. The subjects are divided into two groups: Hypertonic Saline Non-Responders (33 subjects) and Hypertonic Saline Responders (33 subjects). After completion of questionnaires, the subjects will undergo Dry Eye Disease testing and functional nerve testing. Subjects who qualify will be dispensed 4 weeks of preservative free artificial tears and instructed to instill one drop into each eye twice daily. Subjects will return for a follow up visit 4 weeks later (± 4 days), during which subjects will complete the questionnaires again and the Dry Eye Disease tests and functional nerve tests will be repeated.

Detailed Description

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Conditions

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Dry Eye

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Hypertonic Saline Responders

Subjects who qualify as hypertonic saline responders will be instructed to instill 1-2 drops of preservative-free Refresh Optive Advanced Lubricant Eye Drops, which are available over the counter, into each eye twice a day for 28 days.

Group Type EXPERIMENTAL

Preservative-free Refresh Optive Advanced Lubricant Eye Drops

Intervention Type DRUG

over the counter artificial tear

Hypertonic Saline Non-responders

Subjects who qualify as hypertonic saline non-responders will be dispensed the same instructions and treatment as the Hypertonic Saline Responders. They will be instructed to instill 1-2 drops of preservative-free Refresh Optive Advanced Lubricant Eye Drops, which are available over the counter, into each eye twice a day for 28 days.

Group Type EXPERIMENTAL

Preservative-free Refresh Optive Advanced Lubricant Eye Drops

Intervention Type DRUG

over the counter artificial tear

Interventions

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Preservative-free Refresh Optive Advanced Lubricant Eye Drops

over the counter artificial tear

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Group 1 (Hypertonic saline non-responders):

* At least 18 years of age
* Ability to consent
* Diagnosis of Dry Eye Disease (DED) based on:

* Symptoms of DED, shown with SANDE score of 50mm or greater
* Two or more of the following objective signs in the same eye: 1. Schirmer test of 10 mm or less over 5 minutes; 2. Fluorescein tear break-up time (FTBUT) of 7 seconds or less; 3. Meibomian gland expression (MGE) grade of 2 or greater for at least 3 out of 5 glands
* HS response result of one of the following:

* Reduction of discomfort/pain rating
* No change of discomfort/pain rating
* Increase in discomfort/pain rating score of 1 step or less

Group 2 (Hypertonic saline non-responders):

* At least 18 years of age
* Ability to consent
* Diagnosis of DED based on:

* Symptoms of DED, shown with SANDE score 50mm or greater
* Two or more of the following objective signs in the same eye: 1. Schirmer test of 10 mm or less over 5 minutes; 2. Fluorescein tear break-up time (FTBUT) of 7 seconds or less; 3. Meibomian gland expression (MGE) grade of 2 or greater for at least 3 out of 5 glands
* HS response result of an increase in discomfort/pain rating of greater than 1 step

Exclusion Criteria

* Presence of centralized pain as indicated by a proparacaine challenge test (PCT) of less than 50% ocular surface discomfort reduction
* Unable to speak English
* History of ocular surgery, corneal infection, or corneal injury within the last 3 months
* Active ocular allergies or other condition that could impact the study results
* Allergic to benzalkonium chloride "BAK" (an eye-drop preservative)
* Changes in topical or systemic medications in the last 3 months or anticipated changes in medication during the course of treatment
* Use of other topical treatments
* Concurrent enrollment in other studies that in the opinion of the investigator will interfere with the results of this study
* Use of contact lenses within the last month
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tufts Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stephanie Cox, OD

Role: PRINCIPAL_INVESTIGATOR

Tufts Medical Center New England Eye Center

Locations

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Tufts Medical Center-New England Eye Center

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Other Identifiers

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13363

Identifier Type: -

Identifier Source: org_study_id

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