Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients

NCT ID: NCT01118754

Last Updated: 2011-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

132 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to evaluate if DE-101 ophthalmic suspension will safely and effectively improve signs and or symptoms of dry eye disease.

Detailed Description

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Conditions

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Dry Eye

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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DE-101 ophthalmic suspension high dose

Group Type EXPERIMENTAL

DE-101 ophthalmic suspension

Intervention Type DRUG

Ophthalmic suspention; QID

DE-101 ophthalmic suspension low dose

Group Type EXPERIMENTAL

DE-101 ophthalmic suspension

Intervention Type DRUG

Ophthalmic suspention; QID

DE-101 ophthalmic suspension

Intervention Type DRUG

Ophthalmic suspension; QID

DE-101 ophthalmic suspension vehicle

Group Type PLACEBO_COMPARATOR

DE-101 ophthalmic suspension

Intervention Type DRUG

Ophthalmic suspention; QID

DE-101 ophthalmic suspension vehicle

Intervention Type DRUG

ophthalmic suspension vehicle; QID

Interventions

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DE-101 ophthalmic suspension

Ophthalmic suspention; QID

Intervention Type DRUG

DE-101 ophthalmic suspension

Ophthalmic suspension; QID

Intervention Type DRUG

DE-101 ophthalmic suspension vehicle

ophthalmic suspension vehicle; QID

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* confirmed diagnosis of dry eye defined by protocol
* 18 years or older, and sign written informed consent
* negative pregnancy test and utilizing reliable contraceptive throughout study

Exclusion Criteria

* use of any topical ocular medications
* any ocular surgery within 90 days of study
* laser refractive surgery within one year of study
* ocular, lid disease/abnormalities that may interfere with the study
* corneal transplants
* uncontrolled systemic conditions
* females who are pregnant or nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception
* participated in another drug trial within 30 days prior to study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Santen Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Inglewood, California, United States

Site Status

Torrance, California, United States

Site Status

Bloomfield, Connecticut, United States

Site Status

Indianapolis, Indiana, United States

Site Status

New Albany, Indiana, United States

Site Status

Gretna, Louisiana, United States

Site Status

Bangor, Maine, United States

Site Status

Cleveland, Ohio, United States

Site Status

Philadelphia, Pennsylvania, United States

Site Status

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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26-004

Identifier Type: -

Identifier Source: org_study_id