Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease

NCT ID: NCT01239069

Last Updated: 2014-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2011-10-31

Brief Summary

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Investigate the Safety and Efficacy of Two Concentrations of DE-110 Compared to Placebo for the Treatment of Dry Eye Disease

Detailed Description

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Conditions

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Dry Eye

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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DE-110 ophthalmic suspension high dose

Group Type EXPERIMENTAL

DE-110 ophthalmic suspension high dose

Intervention Type DRUG

ophthalmic suspension; high dose; QID

DE-110 ophthalmic suspension low dose

Group Type EXPERIMENTAL

DE-110 ophthalmic suspension low dose

Intervention Type DRUG

ophthalmic suspension; low dose; QID

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

DE-110 ophthalmic suspension vehicle;QID

Interventions

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DE-110 ophthalmic suspension high dose

ophthalmic suspension; high dose; QID

Intervention Type DRUG

DE-110 ophthalmic suspension low dose

ophthalmic suspension; low dose; QID

Intervention Type DRUG

Placebo

DE-110 ophthalmic suspension vehicle;QID

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of dry eye
* Not wear contact lenses during study
* 18 years or older
* Understand and provide written consent
* Negative pregnancy test and use acceptable method of contraception

Exclusion Criteria

* Use of any topical ocular medication
* Any type of ocular surgery
* Diagnosis of on-going ocular infection and/or allergic conjunctivitis
* Uncontrolled systemic conditions/lid abnormalities
* Corneal transplants
* Females who are pregnant, nursing or planning a pregnancy
* Participation in another drug trial concurrently or within 30 days prior to study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Santen Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Inglewood, California, United States

Site Status

Newport Beach, California, United States

Site Status

Petaluma, California, United States

Site Status

Torrance, California, United States

Site Status

Bloomfield, Connecticut, United States

Site Status

Bradenton, Florida, United States

Site Status

Brooksville, Florida, United States

Site Status

Largo, Florida, United States

Site Status

Rosewell, Georgia, United States

Site Status

Louisville, Kentucky, United States

Site Status

Bangor, Maine, United States

Site Status

Cleveland, Ohio, United States

Site Status

San Antonio, Texas, United States

Site Status

Norfolk, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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30-002

Identifier Type: -

Identifier Source: org_study_id

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