Correlation Between Vitamin D and B Regulatory Cell in Pregnancy

NCT ID: NCT04105881

Last Updated: 2019-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-10

Study Completion Date

2020-03-15

Brief Summary

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During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.

Detailed Description

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During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.the fetus is normally accepted by the maternal immune system despite despite the expression of paternal alloantigens. Normally, the fetus grows and develops very well with ongoing pregnancy.

B regulatory cells are increased in pregnant women compared to non-pregnant women.

Conditions

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Labor, Premature

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Full term labor

Measured by flow cytometry and ELUSA

Investigation

Intervention Type DIETARY_SUPPLEMENT

Cross sectional intervention

Preterm labor

Measured by flow cytometry and ELISA

Investigation

Intervention Type DIETARY_SUPPLEMENT

Cross sectional intervention

Control

For comparison

Investigation

Intervention Type DIETARY_SUPPLEMENT

Cross sectional intervention

Interventions

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Investigation

Cross sectional intervention

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* healthy female according to the required groups

Exclusion Criteria

* patient with infectious disease , tuberculosis ,tumor ,hematologic disease,metabolic bone disease or any other connective tissue diseases were excluded.
* Patient with viral hepatitis.
* serological evidence of HIV infection.
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Haitham Mohamed Sedky

Principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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khalid Hassanein

Role: PRINCIPAL_INVESTIGATOR

Microbiology and immunology department

Locations

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Assiut university

Asyut, Asyut Governorate, Egypt

Site Status

Assiut university

Asyut, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Khalid Hassanein, Professor

Role: CONTACT

+20109191208

Helal Hetta, Lecturer

Role: CONTACT

+201002386255

Facility Contacts

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Khalid Hassanein, Professor

Role: primary

+201091912080

Helal Hetta, Lecturer

Role: backup

+201002386255

Khalid Hassanein, Professor

Role: primary

01091912080

Helal Hetta

Role: backup

01002386255

References

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Zahran AM, Zharan KM, Hetta HF. Significant correlation between regulatory T cells and vitamin D status in term and preterm labor. J Reprod Immunol. 2018 Sep;129:15-22. doi: 10.1016/j.jri.2018.07.004. Epub 2018 Jul 18.

Reference Type RESULT
PMID: 30029057 (View on PubMed)

Lima J, Martins C, Leandro MJ, Nunes G, Sousa MJ, Branco JC, Borrego LM. Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study. BMC Pregnancy Childbirth. 2016 Jun 6;16(1):139. doi: 10.1186/s12884-016-0927-7.

Reference Type RESULT
PMID: 27267973 (View on PubMed)

Other Identifiers

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Dear

Identifier Type: -

Identifier Source: org_study_id

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