Augmented Effects of Virtual-reality Cycling Training on Upper Limb Motor Functions by NIBS in Patients With CP
NCT ID: NCT04101994
Last Updated: 2026-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
36 participants
INTERVENTIONAL
2018-06-26
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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VCT and real rTMS
In virtual cycling training and intermittent theta burst stimulation group (VCT + iTBS group), they received VCT and iTBS (80% of active motor threshold) on affected hemisphere.
Virtual cycling training
Virtual cycling training is a convenient and easy approach for muscle strengthening.
Repetitive transcranial magnetic stimulation
Intermittent theta burst stimulation produces short TBS trains intermittently to facilitate cortical excitability.
VCT and sham rTMS
In virtual cycling training and sham theta burst stimulation group (VCT + iTBS group), they received VCT and sham TBS stimulation.
Virtual cycling training
Virtual cycling training is a convenient and easy approach for muscle strengthening.
Repetitive transcranial magnetic stimulation
Intermittent theta burst stimulation produces short TBS trains intermittently to facilitate cortical excitability.
real rTMS
In intermittent theta burst stimulation (iTBS group), they received iTBS (80% of active motor threshold) on affected hemisphere.
Repetitive transcranial magnetic stimulation
Intermittent theta burst stimulation produces short TBS trains intermittently to facilitate cortical excitability.
sham rTMS
In sham theta burst stimulation (sham TBS group), they received sham TBS stimulation.
Repetitive transcranial magnetic stimulation
Intermittent theta burst stimulation produces short TBS trains intermittently to facilitate cortical excitability.
VCT and real TES
In virtual cycling training and transcranial electric stimulation group (VCT + TES group), they received TES stimulation over motor cortex.
Virtual cycling training
Virtual cycling training is a convenient and easy approach for muscle strengthening.
Transcranial electric stimulation
TES is a constant current with low intensity delivered to the skull through surface electrodes.
VCT and sham TES
In virtual cycling training and sham transcranial electric stimulation group (VCT + sham TES group), they received VCT and sham TES stimulation.
Virtual cycling training
Virtual cycling training is a convenient and easy approach for muscle strengthening.
Transcranial electric stimulation
TES is a constant current with low intensity delivered to the skull through surface electrodes.
real TES
In transcranial electric stimulation group (TES group), they received TES stimulation over motor cortex.
Transcranial electric stimulation
TES is a constant current with low intensity delivered to the skull through surface electrodes.
sham TES
In sham transcranial electric stimulation group (sham TES group), they received sham TES stimulation.
Transcranial electric stimulation
TES is a constant current with low intensity delivered to the skull through surface electrodes.
Interventions
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Virtual cycling training
Virtual cycling training is a convenient and easy approach for muscle strengthening.
Repetitive transcranial magnetic stimulation
Intermittent theta burst stimulation produces short TBS trains intermittently to facilitate cortical excitability.
Transcranial electric stimulation
TES is a constant current with low intensity delivered to the skull through surface electrodes.
Eligibility Criteria
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Inclusion Criteria
* Age 5-20 years
* No use of botulinum toxin in the past 4 months
* No significant perceptual or communication disturbances
* No other peripheral or central nervous system dysfunction
* No active inflammatory or pathologic changes in upper limb joints during the previous 6 months
* No active medical problems, such as pneumonia, upper gastrointestinal bleeding, or urinary tract infection
* No active problems of epilepsy and EEG without epileptiform discharge
Exclusion Criteria
* Active infectious disease, such as meningitis and encephalitis
* Patients with active medical problems, such as pneumonia, upper gastrointestinal bleeding, or urinary tract infection
* Poor compliance or intolerance for the TMS therapy
* Subjects with metallic implants or pregnancy.
* EEG show epileptiform discharge
* Patients with family history of epilipsy
* Patients with symptoms that are restricted from tDCS, such as epilepsy, migraine and unstable health condition
5 Years
20 Years
ALL
No
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Principal Investigators
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Chia-Ling Chen, MD, PhD
Role: STUDY_DIRECTOR
Chang Gung Memorial Hospital
Locations
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Chang Gung Memorial Hospital
Taoyuan District, Taoyuan, Taiwan
Countries
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Other Identifiers
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201701518A0
Identifier Type: -
Identifier Source: org_study_id
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