Decision-making - the Benefit of Bedside CRP Within Ambulance Care

NCT ID: NCT04097210

Last Updated: 2022-01-31

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 110 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-01-01
• Study Completion Date: 2021-06-01

Brief Summary

Patients with degreased (DGC) for ambiguous reasons receive low triage priority. Their death risk is triple. Tools are needed to identify the critically ill patients from this group. The triage used today is not effective. The bedside point-of-care measurements are CRP, lactate acid and suPAR (Soluble Urokinase Plasminogen Activator Receptor). Elevated values associate with the probability of critical illness and predict a risk of death.

Detailed Description

Purpose: To improve identification and proper prioritization of patients with non-specific symptoms prehospitally, we intend to investigate whether Q-CRP, a rapid test for CRP, correlates with time-critical states in the above-mentioned patient group alone or together with CRP, lactate and suPAR. The primary endpoint is need for hospital care.

Material: Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room.

Method: In patients with unspecified conditions, defined according to the inclusion template, a venous blood sample was taken prehospitally at the scene by the EMS.

Analysis: Significance tests and regression analyzes with 95% CI were used. The diagnostic accuracy of Q-CRP, lactate, suPAR and combinations thereof were compared with optimal boundary values.

Conditions

Critical Illness

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: RETROSPECTIVE

Interventions

POC

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patients over 18 years who exhibit non-specific symptoms and transported to the emergency room.

Exclusion Criteria

• Abnormal vitals

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 104 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Helsinki University Central Hospital

OTHER

Sponsor Role: lead

Responsible Party

Marja Mäkinen

PhD, principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Maaret Castrén, Professor

Role: STUDY_DIRECTOR

Helsinki University Central Hospital

Johanna Kaartinen, PhD

Role: PRINCIPAL_INVESTIGATOR

Helsinki University Central Hospital

Other Identifiers

HUS 329/13/3/02/2015

Identifier Type: -

Identifier Source: org_study_id