Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in IVF-ET
NCT ID: NCT04079959
Last Updated: 2020-01-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
120 participants
OBSERVATIONAL
2019-09-15
2023-12-31
Brief Summary
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Detailed Description
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Uterine natural killer (uNK) cells have been implicated to play a role in female reproductive performance. They comprise 70-80% of the total leukocyte population in the endometrium during implantation and early pregnancy. Several studies showed an increased uNK cell density in the endometrium of women with reproductive failure. To better understand the contribution of various immune factors to endometrial function and future pregnancy, it is proposed to examine the major immune cells in the same specimen to measure the relative magnitude of the cell density changes and the degree of clustering between two immune cell types.
The aim of this study is to investigate the endometrial leucocytes profile around the time of embryo implantation.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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women who are undergoing frozen embryo transfer
endometrial biopsy will be done one cycle before the frozen embryo transfer
endometrial biopsy
. Endometrial samples are obtained using a biopsy catheter as follows: the Pipette is inserted through the cervical os and advanced gently until resistance is felt. The inner piton of the device is then withdrawn to create suction, and the endometrial sample is obtained by moving the pipette up and down approximately 2-3 cm within the uterine cavity. The device is rotated 360° to ensure adequate coverage of the area.
Interventions
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endometrial biopsy
. Endometrial samples are obtained using a biopsy catheter as follows: the Pipette is inserted through the cervical os and advanced gently until resistance is felt. The inner piton of the device is then withdrawn to create suction, and the endometrial sample is obtained by moving the pipette up and down approximately 2-3 cm within the uterine cavity. The device is rotated 360° to ensure adequate coverage of the area.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Women who have any uterine anomaly or intrauterine pathology such as:
Endometrial polyp or/ and Large fibroid with a diameter \>4 cm
* Visible hydrosalpinx on transvaginal ultrasound scans
* BMI \>35
18 Years
40 Years
FEMALE
No
Sponsors
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Chinese University of Hong Kong
OTHER
Responsible Party
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Chen Xiaoyan
Research Assistant Professor
Principal Investigators
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Xiaoyan Chen, PhD
Role: PRINCIPAL_INVESTIGATOR
Chinese University of Hong Kong
Locations
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The Chinese University of Hong Kong
Hong Kong, , Hong Kong
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2019.277
Identifier Type: -
Identifier Source: org_study_id
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