Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
16 participants
OBSERVATIONAL
2018-02-26
2018-07-12
Brief Summary
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The normal and pathological oocyte cohort after controlled ovarian stimulation will be also characterized by identifying the oocyte leading to live birth.
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Detailed Description
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The oocyte quality evaluation is also subject to controversy. Indeed, its morphological approach remains the most commonly used in routine at the IVF laboratory. However, this tool remains limited and to date, no correlation between oocyte morphology and ART outcomes have been established. In this context, there is a real need to use functional approaches such as genomics, transcriptomics, proteomics and metabolomics. However, the clinical validation and application of these functional tools have to be evaluated from a human pathology model such as endometriosis.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Case : endometriosis
Infertile patients with endometriosis that is the only cause of their infertility
No interventions assigned to this group
Control : tubal factor
infertile patients with tubal factor that is the only cause of their infertility
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
a. Womens with endometriosis i. Deep endometriosis without ovarian localisation ii. Deep endometriosis associated with ovarian localisation iii. Isolated ovarian localisation b. Male partner with normal sperm parameters Group 2 : control
1. Womens with isolated tubal factor
2. Male partner with normal sperm parameters
Exclusion Criteria
* Altered sperm parameters
* Male or female viral risk
* Oocyte or sperm donation
18 Years
FEMALE
No
Sponsors
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URC-CIC Paris Descartes Necker Cochin
OTHER
Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Khaled POCATE-CHERIET, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Locations
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Hôpital Cochin-Port Royal
Paris, Paris, France
Countries
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References
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Pocate-Cheriet K, Santulli P, Kateb F, Bourdon M, Maignien C, Batteux F, Chouzenoux S, Patrat C, Wolf JP, Bertho G, Chapron C. The follicular fluid metabolome differs according to the endometriosis phenotype. Reprod Biomed Online. 2020 Dec;41(6):1023-1037. doi: 10.1016/j.rbmo.2020.09.002. Epub 2020 Sep 4.
Other Identifiers
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2017-A01163-50
Identifier Type: -
Identifier Source: org_study_id
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