Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

NCT ID: NCT04067440

Last Updated: 2025-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2024-07-30

Brief Summary

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Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.

Detailed Description

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Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum.

The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall.

Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.

Conditions

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Obesity Diabetes Mellitus Fatty Liver, Nonalcoholic Leaky Gut Syndrome Chronic Pancreatitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients

Subjects to undergo surgery including opening of the jejunum with non-inflammative condition.

Microbial Swab

Intervention Type DIAGNOSTIC_TEST

Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool

Interventions

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Microbial Swab

Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* abdominal surgery containing opening of jejunum
* singing of consent

Exclusion Criteria

* inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universität des Saarlandes

OTHER

Sponsor Role lead

Responsible Party

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Michael Jelden

Dr. med. Michael Jelden

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael Jelden, Dr.

Role: PRINCIPAL_INVESTIGATOR

Saarland University Hospital

Locations

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Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,

Homburg/Saar, , Germany

Site Status

Countries

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Germany

Other Identifiers

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METABIOM

Identifier Type: -

Identifier Source: org_study_id

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