Growth and Tolerance Trial on Infant Formula With HMO

NCT ID: NCT04066413

Last Updated: 2023-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

265 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-23

Study Completion Date

2023-01-26

Brief Summary

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The aim of the study is to compare growth of healthy infants fed an infant formula supplemented with a human milk oligosaccharide to that of infants on standard formula.

Detailed Description

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Conditions

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Healthy Growth

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Breastfed group

Non-randomized breastfed reference group

Group Type NO_INTERVENTION

No interventions assigned to this group

Control formula

Group receiving standard infant formula

Group Type PLACEBO_COMPARATOR

Standard infant formula

Intervention Type OTHER

Standard infant formula

Formula with HMO

Group receiving standard infant formula supplemented with HMO

Group Type ACTIVE_COMPARATOR

Infant formula supplemented with HMO

Intervention Type OTHER

Infant formula supplemented with HMO

Interventions

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Standard infant formula

Standard infant formula

Intervention Type OTHER

Infant formula supplemented with HMO

Infant formula supplemented with HMO

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Gestational age ≥ 37 weeks
* Birth weight ≥ 2500 grams
* No recognized diseases (such as cardiac, pulmonary, gastrointestinal, renal or genetic diseases)
* Boys and girls
* Recruited \< 1 month/age
* Being available for follow up until the age of 4 months
* Exclusive formula feeding or exclusive breast feeding at time of recruitment

Exclusion Criteria

* Gestational age \<37 weeks
* Birth weight \<2500 grams
* Severe acquired or congenital diseases, mental or physical disorders
* Illness at screening/ inclusion
* Incapability of parents/caregivers to comply with the study protocol
* Received antibiotics within the first month of life
* Not tolerating standard cow's milk based infant formula
* Participation in another clinical trial
* Maternal illicit drug use during pregnancy or post-partum period
* Parent/caregiver does not have a cell phone to use for filling out questionnaires
Maximum Eligible Age

1 Month

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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FrieslandCampina

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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Stardust

Identifier Type: -

Identifier Source: org_study_id

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