The Effect of Delayed Cord Clamping and Milking on the Amount of Stem Cells In Preterm

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-15

Study Completion Date

2020-10-01

Brief Summary

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Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.

In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.

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Detailed Description

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Conditions

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Umbilical Cord; Clamping Time

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Delayed Cord Clamping for 30 seconds

Infants whose umbilical cord clamping will be delayed for 30 secs.

Group Type EXPERIMENTAL

Delayed umbilical cord clamping

Intervention Type PROCEDURE

During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.

Delayed Cord Clamping for 60 seconds

Infants whose umbilical cord clamping will be delayed for 60 secs.

Group Type EXPERIMENTAL

Delayed umbilical cord clamping

Intervention Type PROCEDURE

During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.

Umbilical Cord Milking

Infants whose umbilical cord will be clamped after milking from the distance of 20 cm from mother's side to the baby for 3-4 times.

Group Type EXPERIMENTAL

Cord Milking

Intervention Type PROCEDURE

Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.

Interventions

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Delayed umbilical cord clamping

During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.

Intervention Type PROCEDURE

Cord Milking

Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Infants born under 32 weeks of gestation
* Accepted to participate with informed consent
* History of healthy pregnancy
* Infants born and will be followed up at the study hospital