Treatment-related Benefit and Satisfaction in Fabry Patients. Insight in Patients Expectations and Preferences

NCT ID: NCT04043273

Last Updated: 2024-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

69 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-04

Study Completion Date

2023-01-30

Brief Summary

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In the shared decision-making process, patients should express their expectations and preferences regarding treatment to the physician. A specific questionnaire addressing needs and expectations of Fabry patients has been built at the initiative of Amicus. In addition, this questionnaire also evaluates the benefit of treatment from the patient's perspective. Nothing is known until now on patient's expectations, potential clustering of patients regarding their expectations and evaluation of treatment benefit from the patients perspective.

Study objectives are differentiated according to the study phase (inclusion and follow-up). At inclusion, the primary objective is to cluster patients according to their needs and expectations regarding treatment. During follow-up, the primary objective is to evaluate treatment benefit in relation with patients needs and expectations.

Detailed Description

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Prospective, longitudinal, non-comparative, open-label, multicentre, non interventional cohort study.

Conditions

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Fabry Disease Anderson Fabry Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Whole cohort

The whole cohort will be divided into clusters according to patients expectations and preferences regarding their treatment

Noninterventional characterization of patients expectations and preferences regarding their treatment

Intervention Type BEHAVIORAL

Patients will be clustered before and after a principal components analysis (PCA) on Patients Needs Questionnaire (PNQ). Observations will be clustered by the Ward method. The number of clusters will be chosen using the Kolinski criteria. Characteristics of patients will be described by cluster.

Interventions

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Noninterventional characterization of patients expectations and preferences regarding their treatment

Patients will be clustered before and after a principal components analysis (PCA) on Patients Needs Questionnaire (PNQ). Observations will be clustered by the Ward method. The number of clusters will be chosen using the Kolinski criteria. Characteristics of patients will be described by cluster.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Patients ≥ 16 years old
* Diagnosed with Fabry disease
* With amenable mutation
* Decision by clinician to start or pursue ongoing ERT or migalastat
* Non-opposition form to participate in the study signed

Exclusion Criteria

\- Concomitant patient participation in an interventional clinical study (Category 1 interventional research or category 2 interventional research according to the Jardé law classification in France)
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Amicus Therapeutics France SAS

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Olivier Lidove, MD

Role: PRINCIPAL_INVESTIGATOR

Groupe Hospitalier Diaconesses Croix Saint-Simon

Locations

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CHU d'Angers

Angers, , France

Site Status

CHU Pellegrin

Bordeaux, , France

Site Status

Hôpital Côte de Nacre

Caen, , France

Site Status

CHU de Dijon

Dijon, , France

Site Status

CHRU de Lille

Lille, , France

Site Status

Hôpital Femme Mère Enfant

Lyon, , France

Site Status

Hôpital de la Conception

Marseille, , France

Site Status

CHU de Nantes

Nantes, , France

Site Status

Hopital Tenon

Paris, , France

Site Status

Groupe Hospitalier Diaconesses Croix Saint-Simon

Paris, , France

Site Status

CHU de Rennes

Rennes, , France

Site Status

CHU de Rouen

Rouen, , France

Site Status

CHU de Strasbourg

Strasbourg, , France

Site Status

CHU de Toulouse

Toulouse, , France

Site Status

CHU de Tours

Tours, , France

Site Status

Countries

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France

Other Identifiers

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SATIS-Fab

Identifier Type: -

Identifier Source: org_study_id

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