Crizotinib in c-MET Mutation Metastatic/Recurrent/Persistent Endometrial Cancer

NCT ID: NCT04030429

Last Updated: 2025-07-16

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-01
• Study Completion Date: 2025-06-01

Brief Summary

The majority of endometrial cancer patients with disease spread beyond the uterus will progress within 1 year. Platinum-based chemotherapy was used as the first-line treatment in metastatic or advanced endometrial cancer. There is no standard protocol for the second-line option when tumors persist or recur. In vitro and in vivo studies showed Crizotinib, an approved drug for the treatment of ALK-positive non-small cell lung cancer, demonstrated activities in endometrial cancer with c-MET kinase and Sema domain mutations. As a consequence, a phase 2 clinical trial to investigate the efficacy of Crizotinib in endometrial cancer patients with MET mutation is initiated.

Detailed Description

In this phase 2 study, the target population is patients with recurrent or persistent metastatic endometrial cancer. The mutation status of c-MET gene will be tested and only patients with c-MET mutation will be enrolled. After enrollment, Crizotinib 250 mg bid will be used orally. CT scan or MRI will be used to determine the response. Crizotinib will be continued till disease progression. Primary end is objective response rate. The secondary endpoints include progression-free survival, overall survival and safety profiles.

Conditions

Endometrial Cancer Recurrent

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Crizotinib arm

Crizotinib 250 mg bid orally

Group Type: EXPERIMENTAL

Crizotinib 250 MG

Intervention Type: DRUG

bid orally

Interventions

Crizotinib 250 MG

bid orally

Intervention Type: DRUG

Other Intervention Names

Xalkori 250 MG

Eligibility Criteria

Inclusion Criteria

• Age no less than 20 years and no more than 75 years, at the time of acquisition of informed consent.
• Histological confirmed epithelial endometrial cancer
• Disease recurrent after curative therapy or adjuvant therapy including surgery, chemotherapy, radiotherapy or hormone therapy
• Metastatic/recurrent/persistent endometrial cancer
• Tumor tissue with high expression in immunohistochemistry stain (IHC) or somatic c-MET mutation
• Patients with symptomatic recurrent lesion or Image diagnosis (including ultrasound, Computed Tomography or Magnetic Resonance Imaging) recurrent status
• ECOG Performance status 0-2
• At least one distinct tumor, not previous irradiated, measurable lesion according to RECIST (version 1.1)
• Adequate organ function

Bone marrow:

Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L WBC ≥ 3.0 x 10^9/L Platelet count ≥ 100 x 10^9/L Hemoglobin ≥ 9 g/dL

Hepatic:

Total bilirubin level ≤ 1.0 x UNL AST and ALT ≤ 3.0 x UNL Renal: Creatinine level ≤ 1.5 mg/dL in men, ≤1.4 mg/dL in women; or Estimated CCr ≥ 60 mL/min (CCr is estimated by Cockcroft-Gault formula)

• Negative pregnancy test for women of childbearing potential only
• Patient willing to provide blood sample for research purposes
• Written informed consent

Exclusion Criteria

• Presence or history of malignancy disease other than endometrial cancer that has been diagnosed with past five years
• Other anti-tumor agent such as systemic chemotherapy, hormone therapy or surgery within 2 weeks before the commencement of study treatment or radiotherapy within 4 weeks before the commencement of study
• Active uncontrolled infection
• Significant medical diseases, such as unstable angina, acute or recent myocardial infarction (<6 months before enrollment), COPD with frequent exacerbation, uncontrolled hypertension, ore cent CVA (<6 months before enrollment)
• Poor compliance
• Pregnant or breastfeeding women, where pregnancy is confirmed by a positive hCG laboratory test.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chi Mei Medical Hospital

OTHER

Sponsor Role: collaborator

Kaohsiung Medical University

OTHER

Sponsor Role: collaborator

Kaohsiung Veterans General Hospital.

OTHER

Sponsor Role: collaborator

National Cheng-Kung University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Keng-Fu Hsu, PhD

Role: PRINCIPAL_INVESTIGATOR

National Cheng-Kung University Hospital

Locations

National Cheng Kung University Hospital

Tainan City, Taiwan, Taiwan

Countries

Taiwan

Other Identifiers

B-BR-108-016

Identifier Type: -

Identifier Source: org_study_id