Effects of PARP Inhibitor on Tumor Microenvironment in High-risk Endometrial Cancer Patients

NCT ID: NCT05320757

Last Updated: 2025-06-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-04-01
• Study Completion Date: 2025-05-31

Brief Summary

This is a window study where treatment-naïve patients will receive olaparib before definitive treatment. The aim is to evaluate the DNA damage and inflammatory response after PARP inhibitor.

Detailed Description

Patients with high-risk endometrial cancers are prone to develop recurrence. The response rate to conventional chemotherapy in persistent or recurrent endometrial cancer is poor. Recent research demonstrated that immune checkpoint with or without targeted therapy was an effective treatment option. However, the change of immune landscape in the blood and tumor after PARPi is not clear.

Conditions

Endometrial Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Olaparib

Olaparib: 300mg BID orally for 10 - 28 days (stop 3 - 4 days before definitive treatment)

Group Type: EXPERIMENTAL

Olaparib

Intervention Type: DRUG

a PARP inhibitor

Interventions

Olaparib

a PARP inhibitor

Intervention Type: DRUG

Other Intervention Names

Lynparza

Eligibility Criteria

Inclusion Criteria

1. Patients must be capable of giving signed informed consent

2. Patients must be at least 18 years old

3. Patients must have newly diagnosed and histologically confirmed high-risk endometrial cancer, including:

1. G3 endometrioid, any stage

2. Type 2 (such as serous, clear cell, carcinosarcoma), any stage

3. G1 endometrioid, stage 2 or beyond

4. The endometrial cancer should be visible on pre-treatment ultrasound, or endometrial lining should be 5mm or above

5. An archived FFFE sample of endometrial biopsy or at least 8 unstained slides should be available

6. Patients should have Eastern Cooperative Oncology Group (ECOG) performance score 0 to 1

7. Patients must have adequate bone marrow, renal, hepatic, thyroid and neurological function within 28 days prior to administration of study treatment

8. Patients must be able to swallow oral medication

9. Patients must have a life expectancy of ≥ 16 weeks

10. Patients must either be postmenopausal or show evidence of non-childbearing status for women of childbearing potential

Exclusion Criteria

1. Patients with other malignancy unless curatively treated with no evidence of disease for >= 5 years, are excluded.

2. Patients whose resting ECG indicating uncontrolled, potentially reversible cardiac conditions, or patients with congenital long QT syndrome, are excluded.

3. Patients with myelodysplastic syndrome/acute myeloid leukaemia or with features suggestive of MDS/AML, other hematological diseases such as venous or arterial thrombosis and thrombocytopenia are excluded.

4. Patients with symptomatic uncontrolled brain metastases are excluded.

5. Patients who are unable to swallow orally administered medication and gastrointestinal disorders are excluded.

6. Patients with immunocompromised condition, active hepatitis, or persistent toxicities caused by previous cancer therapy, are excluded.

9. Concomitant use of known strong CYP3A inhibitors or inducer are excluded. 10. Patients who have major surgery within 2 weeks, previous allogenic bone marrow transplant, are excluded.

11. Patients with a known hypersensitivity to olaparib or any of the excipients of the product are excluded.

12. Use of an investigational drug within 30 days or 5 half-lives, whichever is longer, proceeding the first dose of study drug is not allowed.

13. Pregnant or breastfeeding women are excluded. 14. Patients who are judged by the investigator to be unlikely to comply with study procedures, restrictions and requirements are excluded.

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

The University of Hong Kong

OTHER

Sponsor Role: lead

Responsible Party

Dr. Ka-Yu Tse

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ka Yu Tse

Role: PRINCIPAL_INVESTIGATOR

The University of Hong Kong

Locations

The University of Hong Kong

Hong Kong, , Hong Kong

Countries

Hong Kong

Other Identifiers

UW 21-521

Identifier Type: -

Identifier Source: org_study_id