MICROBIOLOGY OF CEREBRAL ABSCESSES

NCT ID: NCT04018742

Last Updated: 2019-07-16

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-10-01
• Study Completion Date: 2023-10-30

Brief Summary

Establish the repertoire of bacteria and Archaea responsible for brain abscesses. Correlate the microbial repertoire to epidemiological, clinical and radiological data; to define the different nosological entities falling within the framework of cerebral abscesses.

Detailed Description

Brain abscess is a fatal infectious pathology of the central nervous system for which our CHU provides a referent function and supports patients suspected and diagnosed with a cerebral abscess in the area of the regional hospital group (GHT). Through the routine activity of the Microbiology laboratory of the IHU Méditerranée Infection, more than 180 diagnosed patients have been investigated in 9 years, an average of 20 patients per year. The mortality of brain abscesses is currently measured at 15% despite well-established diagnostic and therapeutic protocols in the literature, associating surgical drainage of abscess and administration of probabilistic antibiotics. Our hypothesis is that established protocols take into account incomplete microbiological documentation of cerebral abscesses and therefore anti-infectious therapy that may not be strictly adapted to the causative microorganisms. Our hypothesis is based on our own work as well as the literature data, showing that current approaches only target bacteria but that these approaches leave aside other living worlds such as Archaea. Indeed, investigators have recently shown for the first time that methanogens, which are Archaea microorganisms, constitute part of the flora responsible for certain cerebral abscesses and that they have a direct pathogenic role in cerebral abscesses. More specifically, the diagnosis of cerebral abscess includes several clinical and microbiological situations that are not all of the same therapeutic. Investigator propose to collect 20 abscesses. A collection of abscesses is performed systematically during the diagnosis for bacteriological analysis. There will be no further examination. The main objective of this clinical research project is to establish the repertoire of microorganisms responsible for brain abscesses; and as a secondary objective to define the different clinical entities forming the cerebral abscesses.

Conditions

Brain Abscess

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with an abscess

Patient diagnosed with a cerebral abscess at admission; and to benefit from an abscess puncture as part of routine care.

Surgical puncture

Intervention Type: OTHER

Investigators propose to collect 20 abscesses. A collection of abscesses is performed systematically during the diagnostic for bacteriological analysis. There will be no further examination.

Interventions

Surgical puncture

Investigators propose to collect 20 abscesses. A collection of abscesses is performed systematically during the diagnostic for bacteriological analysis. There will be no further examination.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient diagnosed with a cerebral abscess at admission; and to benefit from an abscess puncture as part of routine care.
• Affiliate or beneficiary of a social security scheme.

Exclusion Criteria

• Pregnant or nursing woman.
• Major patient under tutorship or curatorship.
• Patient deprived of liberty or under a court order
• Patient refusing to participate in the study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Didier Raoult

Role: CONTACT

didier.raoult@gmail.com

04 13 73 20 51

Alexandra Giuliani

Role: CONTACT

promotion.interne@aphm.fr

04 91 38 28 70

Other Identifiers

2018-59

Identifier Type: REGISTRY

Identifier Source: secondary_id

2018-59

Identifier Type: -

Identifier Source: org_study_id