Nitric Oxide Lung Diffusing Capacity in Healthy, Non-smoking Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-01-31

Brief Summary

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The measurement of nitric oxide lung diffusing capacity (DLNO) has been recently standardised. To date, two pulmonary function devices are commercially available and are used for the measurement of DLNO. No previous study assessed differences in gas exchange outcomes (e.g., DLNO values) between both devices.

The aim of this project is to compare two commercially available devices that measure lung diffusing capacity for nitric oxide (DLNO).

1. "MasterScreenTM" (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany
2. "HypAir" ("HA", Medisoft, Dinant, Belgium).

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Detailed Description

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In a single-center, crossover study conducted at the University Hospital Zurich, Switzerland, 35 healthy, non-smoking adults (\>=18 years) will be invited to perform DLNO measurements in random order using the MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium) devices during one study visit.

The order of the tests on the MasterscreenTM and HypAir devices will be randomly allocated using central randomisation.

Conditions

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Healthy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Lung diffusing capacity measurements

Participants perform single-breath lung diffusing capacity measurements in random order during one study visit.

Jaeger Masterscreen TM

Intervention Type DEVICE

Single-breath nitric oxide lung diffusing capacity

HypAir Medisoft

Intervention Type DEVICE

Single-breath nitric oxide lung diffusing capacity

Interventions

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Jaeger Masterscreen TM

Single-breath nitric oxide lung diffusing capacity

Intervention Type DEVICE

HypAir Medisoft

Single-breath nitric oxide lung diffusing capacity

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

\- Age 18 years and older

Exclusion Criteria

* Previous thoracic surgery
* Smoking
* Chronic lung disease (e.g., asthma bronchiale, COPD)
* Forced expiratory volume in 1s and/or forced vital capacity below the lower limit of normal based on spirometry \[Quanjer et al. Eur Respir J 2005\]
* Current respiratory infection

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes