Role of Oxygen for Vascular Dysfunction

NCT ID: NCT02127333

Last Updated: 2014-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2013-09-30

Brief Summary

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Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.

Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.

We hypothesize that hypoxemia leads to impaired vascular function.

Detailed Description

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Conditions

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Endothelial Dysfunction FMD IMT Microcirculation Oxygen Pressure Carbon Dioxide Pressure Oxygen Saturation Forced Expiratory Volume After 1 Second

Keywords

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chronic obstructive pulmonary disease Coronary artery disease Endothelial function

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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CAD patients with COPD

No interventions assigned to this group

CAD patients without COPD

No interventions assigned to this group

healthy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* stable coronary artery disease
* stable chronic obstructive pulmonary disease

Exclusion Criteria

* acute myocardial infarction within 30 days
* acute exacerbated COPD within 30 days
* acute infections
* severe acute or chronic renal failure
* severe heart failure
* atrial fibrillation
* severe cardiac arrhythmia
* hypotension
* active malignant disease
* active rheumatic disease
* pulmonary hypertension with vasoactive therapy
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Klinik für Kardiologie, Pneumologie und Angiologie

OTHER

Sponsor Role lead

Responsible Party

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Klinik für Kardiologie, Pneumologie und Angiologie

Division of Cardiology, Pulmonary Diseases, Vascular Medicine

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Christian Heiss, MD

Role: PRINCIPAL_INVESTIGATOR

Division of Cardiology, Pulmonary Disease and Vascular Medicine

Malte Kelm, MD

Role: STUDY_CHAIR

Division of Cardiology, Pulmonary Disease and Vascular Medicineine

Locations

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Division of Cardiology, Pulmonary Disease and Vascular Medicine

Düsseldorf, , Germany

Site Status

Countries

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Germany

Related Links

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Other Identifiers

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COPD_pO2

Identifier Type: -

Identifier Source: org_study_id