Helmet CPAP vs Facemask CPAP in ACPE (hCPAP vs fCPAP)

NCT ID: NCT04014088

Last Updated: 2025-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

164 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-01

Study Completion Date

2018-01-10

Brief Summary

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This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Edema (ACPE) patients in the Emergency Department (ED) delivered by helmet CPAP (hCPAP) and facemask CPAP (fCPAP).Patients will be randomized to receive either hCPAP or fCPAP.

Detailed Description

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Non-invasive ventilation(NIV) has different types of interfaces that had been used in acute cardiogenic pulmonary edema. The appropriate interface is necessary to provide comfort and lead to the success of NIV.

NIV delivered via facemask had been used widely. However, it was associated with leaks and discomfort to the patient.

Helmet continuous positive airway pressure (hCPAP) is an NIV interface that allows the provision of high airway pressures with a minimal leak.

Conditions

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Acute Cardiogenic Pulmonary Edema

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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helmet CPAP

helmet CPAP administer to patient diagnosed as acute cardiogenic pulmonary edema

Group Type ACTIVE_COMPARATOR

hCPAP vs fCPAP

Intervention Type DEVICE

The patient presented with Acute Cardiogenic Pulmonary Edema will be randomized into either helmet CPAP or facemask CPAP.

facemask CPAP

facemask CPAP administer to patient diagnosed as acute cardiogenic pulmonary edema

Group Type ACTIVE_COMPARATOR

hCPAP vs fCPAP

Intervention Type DEVICE

The patient presented with Acute Cardiogenic Pulmonary Edema will be randomized into either helmet CPAP or facemask CPAP.

Interventions

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hCPAP vs fCPAP

The patient presented with Acute Cardiogenic Pulmonary Edema will be randomized into either helmet CPAP or facemask CPAP.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All patients aged more than 18 years old presented with acute cardiogenic pulmonary oedema

Exclusion Criteria

1. Age less than 18 years old
2. Low GCS (less than 8), altered mental status
3. Hemodynamic instability, impending cardiopulmonary arrest
4. Use of vasopressors, inotropes
5. Exacerbation of asthma or chronic respiratory failure
6. Urgent need for endotracheal intubation
7. Absence of airway protective gag reflex
8. Elevated intracranial pressure
9. Tracheostomy
10. Pregnant
11. Upper airway obstruction
12. Injuries or surgery to head and neck less than 6 months upon presentation
13. Claustrophobia
14. Blind or poor vision
15. Medico-legal related cases
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Raja Permaisuri Bainun

OTHER_GOV

Sponsor Role lead

Responsible Party

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Dr. Adi Bin Osman

Emergency Medicine Consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Adi Osman

Role: PRINCIPAL_INVESTIGATOR

Emergency Department, Hospital Raja Permaisuri Bainun

Other Identifiers

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NMRR-14-1894-21782 (IIR).

Identifier Type: -

Identifier Source: org_study_id

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