Home-Based Fluid Status Monitoring in Heart Failure Patients

NCT ID: NCT04013373

Last Updated: 2021-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

92 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-09

Study Completion Date

2021-07-30

Brief Summary

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This is a prospective, multi-center, single-arm study enrolling adult patients who have been hospitalized for heart failure and subsequently discharged. For the duration of study participation, patients will obtain daily at-home bioimpedance measurements. Heart failure symptoms, medications, and re-hospitalizations will be tracked. Additionally, quality of life questionnaires will be administered at the beginning and end of study participation.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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BIS home-based monitoring

SOZO Bioimpedance Spectroscopy Device

Intervention Type DEVICE

Bioimpedance spectroscopy measurements for assessment of fluid status

Interventions

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SOZO Bioimpedance Spectroscopy Device

Bioimpedance spectroscopy measurements for assessment of fluid status

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age 21 years or older
2. NYHA Class II or III at the time of study enrollment
3. Undergoing discharge following hospitalization for acute heart failure
4. Planned continued treatment for heart failure
5. Patient is able to stand or sit upright for bioimpedance spectroscopy measurements
6. Patient reports access to reliable Wi-Fi connection at home
7. Patient reports adequate space for the SOZO device at home
8. Patient provides written informed consent and authorization to use and disclose health information, including willingness to comply with study procedures

Exclusion Criteria

1. Patient has an implanted cardiac rhythm management device (pacemaker or implantable cardioverter defibrillator)
2. Patient has a confirmed diagnosis of acute coronary syndrome during current admission
3. Patient is enrolled in a concurrent interventional study of an experimental treatment that may confound the results of this study, in the investigator's opinion
4. Patient has a clinical condition that would not allow them to complete the study
5. Patient has had surgical revascularization using saphenous vein grafting that may affect venous return
6. Patient is pregnant or lactating
7. Patient has nephrotic syndrome or nephrosis
8. Patient has end-stage renal disease requiring chronic dialysis
9. Patient has been diagnosed with lymphedema
10. Patient has chronic liver failure or cirrhosis
11. Patient has been diagnosed with thrombophlebitis or deep vein thrombosis in arms or legs in the past 90 days
12. Patient has an amputation of a limb \[Exception: amputation of digits may not affect bioimpedance spectroscopy measurements and will be permitted at the discretion of the study sponsor\]
13. Patient has any other medical condition that, in the opinion of the investigator, will impair the subject's ability to complete study procedures or participate in the protocol
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ImpediMed Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James T Heywood, MD

Role: PRINCIPAL_INVESTIGATOR

Scripps Clinic

Locations

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Alliance Research Institute

Canoga Park, California, United States

Site Status

Du Cardiology

Encinitas, California, United States

Site Status

San Diego Cardiovascular Associates

Encinitas, California, United States

Site Status

SC Clinical Research

Garden Grove, California, United States

Site Status

Scripps Clinic, John R. Anderson V Medical Pavilion

La Jolla, California, United States

Site Status

MD Strategies Research Centers

National City, California, United States

Site Status

Heart Care Associates

Oceanside, California, United States

Site Status

Blue Coast Cardiology

Vista, California, United States

Site Status

Research Alliance

Clearwater, Florida, United States

Site Status

Infinite Clinical Research

Doral, Florida, United States

Site Status

International Research Associates

Miami, Florida, United States

Site Status

Amavita Health

North Miami Beach, Florida, United States

Site Status

Broward Research Center

Pembroke Pines, Florida, United States

Site Status

Flint Cardiovascular

Flint, Michigan, United States

Site Status

Sierra Clinical Research

Las Vegas, Nevada, United States

Site Status

Countries

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United States

References

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Accardi AJ, Matsubara BS, Gaw RL, Daleiden-Burns A, Heywood JT. Clinical Utility of Fluid Volume Assessment in Heart Failure Patients Using Bioimpedance Spectroscopy. Front Cardiovasc Med. 2021 Apr 7;8:636718. doi: 10.3389/fcvm.2021.636718. eCollection 2021.

Reference Type DERIVED
PMID: 33898536 (View on PubMed)

Other Identifiers

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IPD-HBHF-001

Identifier Type: -

Identifier Source: org_study_id

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