Optimization of Spontaneous Postoperative Trial of Void Among Women

NCT ID: NCT04010656

Last Updated: 2021-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

183 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-10

Study Completion Date

2021-12-30

Brief Summary

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Trial of void (TOV) is a diagnostic test performed on all women who undergo prolapse repair or incontinence surgery, due to the importance of diagnosing postoperative urinary retention (POUR). Incidence of POUR may be as high as 62% in some studies. Timely and accurate diagnosis is important to avoid complications such as urinary tract infection, bladder overdistension, and permanent bladder injury. Despite the frequent use of TOV, there is no gold standard for the test, and it likely has poor specificity, leading to discharge of more patients with catheter than required. This prospective cohort study will seek to establish evidence-based optimal parameters for spontaneous trial of void, a TOV modality that has merit for further evaluation given lower theoretical risk of urinary tract infection.

Detailed Description

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Patients will learn to perform self-catheterization ('clean intermittent catheterization', or CIC) preoperatively; after surgery, the investigators will collect a range of voiding parameters used during different TOV protocols (including minimum voided volume \[MVV\], post-void residual via bladder scanner \[PVR\], subjective force of urinary stream \[sFOS\]). Patients will discharge home to perform CIC until two sequential post-void residuals of less than half the volume voided have been achieved. The rate of voiding dysfunction and resulting PVRs will be used to compare the diagnostic accuracy of the perioperative voiding parameters to predict need to perform CIC and post-operative urinary retention.

Conditions

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Urinary Retention Postoperative Voiding Disorders

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Subjects will be taught to perform self-catheterization prior to prolapse repair or incontinence surgery; voiding data will be collected on the participant's first void after surgery. Participants will be discharged home to perform self-catheterization until post-void residual is less than half the volume voided on 2 sequential voids to assess actual voiding function, and this data will be used to calculate the diagnostic accuracy of pre-determined combinations of the TOV parameters.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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PVR-based home self-catheterization

Patients will learn to self-catheterize preoperatively prior to urogynecology surgery requiring trial of void. First post-operative void will be used to collect basic information about voiding function. All participants will leave the hospital and self-catheterize until they achieve two sequential voids with post-void residual (PVR) less than half the volume voided. The cases of urinary retention captured with abnormal PVR will be used to compare the diagnostic accuracy of several commonly-used, pre-defined parameters for trial of void.

Group Type EXPERIMENTAL

PVR-based self-catheterization

Intervention Type PROCEDURE

Home self-catheterization based on standard of care

Interventions

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PVR-based self-catheterization

Home self-catheterization based on standard of care

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* English-speaking women, age \>18yo
* Scheduled for urogynecology procedure which will need post-operative trial of void (including pelvic organ prolapse and/or stress urinary incontinence repair), with plan for same-day discharge.

Exclusion Criteria

* Unable or unwilling to perform self-catheterizatoin either by patient or willing family member
* Pre-existing voiding dysfunction defined as documented PVR \> 200 mL
* Intraoperative urinary tract injury needing indwelling catheter on discharge
* Need for overnight admission
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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American Urogynecologic Society

OTHER

Sponsor Role collaborator

American Association of Gynecologic Laparoscopists

OTHER

Sponsor Role collaborator

Women and Infants Hospital of Rhode Island

OTHER

Sponsor Role lead

Responsible Party

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Anne Cooper, MD

Assistant Professor of Urogynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anne C Cooper, MD, MA

Role: PRINCIPAL_INVESTIGATOR

Dartmouth-Hitchcock Medical Center, Lebanon NH

Julia Shinnick, MD

Role: PRINCIPAL_INVESTIGATOR

Women & Infants Hospital, Providence RI

Locations

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Women & Infants Hospital

Providence, Rhode Island, United States

Site Status

Countries

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United States

References

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Other Identifiers

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WIH IRB 1145237

Identifier Type: -

Identifier Source: org_study_id

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