A Registered Cohort Study on Spastic Paraplegia

NCT ID: NCT04006418

Last Updated: 2022-01-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-07-01

Study Completion Date

2049-12-31

Brief Summary

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The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..

Detailed Description

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Conditions

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Spastic Paraplegia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with the clinical diagnosis of spastic paraplegia
* Clinical diagnosis of patients with spastic paraplegia
* Unrelated healthy controls

Exclusion Criteria

* Decline to participate.
* There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wan-Jin Chen

OTHER

Sponsor Role lead

Responsible Party

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Wan-Jin Chen

The Vice-Director for the Department of Neurology

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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First Affiliated Hospital Fujian Medical University

Fuzhou, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yi Lin, MD,PhD

Role: CONTACT

+13615039153

Wan-Jin Chen, MD,PhD

Role: CONTACT

+1386061359 ext. +1386061359

Facility Contacts

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Wan-Jian Chen, MD, PhD

Role: primary

References

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Zhang F, Hu J, Xiao Z, Lin C, Huang Z, Wang N, Liu Y. Spinal cord cross sign: a potential marker for hereditary spastic paraplegia type 5. Neuroradiology. 2025 Apr;67(4):1081-1090. doi: 10.1007/s00234-025-03543-y. Epub 2025 Jan 24.

Reference Type DERIVED
PMID: 39853345 (View on PubMed)

Tu Y, Liu Y, Fan S, Weng J, Li M, Zhang F, Fu Y, Hu J. Relationship between brain white matter damage and grey matter atrophy in hereditary spastic paraplegia types 4 and 5. Eur J Neurol. 2024 Aug;31(8):e16310. doi: 10.1111/ene.16310. Epub 2024 Apr 23.

Reference Type DERIVED
PMID: 38651515 (View on PubMed)

Qiu YS, Zeng YH, Yuan RY, Ye ZX, Bi J, Lin XH, Chen YJ, Wang MW, Liu Y, Yao SB, Chen YK, Jiang JY, Lin Y, Lin X, Wang N, Fu Y, Chen WJ. Chinese patients with hereditary spastic paraplegias (HSPs): a protocol for a hospital-based cohort study. BMJ Open. 2022 Jan 11;12(1):e054011. doi: 10.1136/bmjopen-2021-054011.

Reference Type DERIVED
PMID: 35017251 (View on PubMed)

Lin Q, Liu Y, Ye Z, Hu J, Cai W, Weng Q, Chen WJ, Wang N, Cao D, Lin Y, Fu Y. Potential markers for sample size estimations in hereditary spastic paraplegia type 5. Orphanet J Rare Dis. 2021 Sep 19;16(1):391. doi: 10.1186/s13023-021-02014-w.

Reference Type DERIVED
PMID: 34538260 (View on PubMed)

Other Identifiers

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MRCTA,ECFAH OF FMU[2019]194

Identifier Type: -

Identifier Source: org_study_id

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