Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy

NCT ID: NCT00680264

Last Updated: 2023-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

402 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-30

Study Completion Date

2025-12-31

Brief Summary

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The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.

Detailed Description

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Bracing severe neuromuscular scoliotic curves rarely serves as definitive treatment, thus most progressive curves require surgical intervention in order to sustain or improve sitting (or ambulatory) abilities. Surgery is a demanding intervention for these patients, with variable functional gains. Controversy persists regarding indications for surgery, timing, and technique. Concerns about complications are paramount. Previous neuromuscular studies have been confined to a small number of surgeons with a narrow range of surgical instrumentation, technique, and correction. Very little evidence exists regarding the impact spinal surgery on the quality of life in children with scoliosis related to cerebral palsy. The instruments to measure quality of life are not specific to children with scoliosis related to cerebral palsy. There have been no comprehensive prospective studies published. This study would be the first large-scale prospective, multi-center series of spinal fusion outcomes in patients with Cerebral Palsy.

Conditions

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Cerebral Palsy Scoliosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Operative

Diagnosis of Cerebral Palsy (standard definition of any brain injury before the age of 3) with total body involvement - any functional level Curve \>40 degrees on sitting film, A spinal fusion is being undertaken and the patient/family is proceeding with the spinal fusion (with any level of distal fusion).

No interventions assigned to this group

Non-operative

Diagnosis of Cerebral Palsy (standard definition of any brain injury before the age of 3) with total body involvement - any functional level, Curve \>40 degrees on sitting film, A spinal fusion is not being undertaken either because the family has refused surgery or because it is not recommended at this point.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient age 8-21 years
* Diagnosis of Cerebral Palsy (standard definition of any brain injury before the age of 3) with total body involvement - any functional level
* Coronal Curve \>50 degrees on sitting film (as measured by 'greatest Cobb') OR Kyphotic curve \>70 degrees on sitting film (as measured by T5-T12) AND
* A spinal fusion is being undertaken and the patient/family is proceeding with the spinal fusion (with any level of distal fusion).

OR

• A spinal fusion is not being undertaken (Non-Operative cohort) either because the family has refused surgery or because it is not recommended at this point or surgery is recommended but is not being undertaken because they are on a waiting list, and are being enrolled as a non-op patient because they will be on the waiting list for \>18 months.

Exclusion Criteria

* Previous operated scoliotic spine deformity
* Diagnosis of Rett's Syndrome
* Concomitant lower extremity surgery (within 3 months of spinal fusion)
Minimum Eligible Age

8 Years

Maximum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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K2M, Inc.

INDUSTRY

Sponsor Role collaborator

Setting Scoliosis Straight Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Paul Sponseller, MD

Role: PRINCIPAL_INVESTIGATOR

John's Hopkins Hospital

Peter Newton, MD

Role: STUDY_DIRECTOR

Rady Children's Hospital San Deigo

Michelle Marks, PT, MA

Role: STUDY_CHAIR

Harms Study Group

Locations

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Rady Children's Hospital

San Diego, California, United States

Site Status RECRUITING

A.I. Dupont Hospital for Children

Wilmington, Delaware, United States

Site Status RECRUITING

Miami Children's Hospital

Miami, Florida, United States

Site Status RECRUITING

Johns Hopkins Medical Institute

Baltimore, Maryland, United States

Site Status RECRUITING

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

New York University Hospital for Joint Diseases

New York, New York, United States

Site Status RECRUITING

Columbia University

New York, New York, United States

Site Status RECRUITING

Cincinnati Children's Hospital

Cincinnati, Ohio, United States

Site Status RECRUITING

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Shriners Hospital for Children

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Texas Scottish Rite Hospital

Dallas, Texas, United States

Site Status RECRUITING

Kluge Children's Rehab. Ctr.

Charlottesville, Virginia, United States

Site Status RECRUITING

CHU Saint-Justine Hospital

Montreal, , Canada

Site Status RECRUITING

Hospital for Sick Children

Toronto, , Canada

Site Status RECRUITING

British Columbia Children's Hospital

Vancouver, , Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Michelle C. Marks, PT, MA

Role: CONTACT

619-810-1430

Facility Contacts

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Petya Yorgova

Role: primary

302-651-6518

Marjolaine Roy-Beaudry

Role: primary

Isabelle Turgeon

Role: backup

Related Links

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http://hsg.settingscoliosisstraight.org/current-hsg-research/

Setting Scoliosis Straight Website - highlighting the research of the Harms Study Group

Other Identifiers

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2007HSG021

Identifier Type: -

Identifier Source: org_study_id

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