Use of Multiparametric MRI in the Management of Head and Neck Cancer: a Retrospective Analysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-01

Study Completion Date

2018-09-30

Brief Summary

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The investigators aim to identify specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region.

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Detailed Description

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Background:The locoregional control rates in patients with advanced head and neck cancer remain suboptimal. Accurate diagnosis of metastatic cervical lymph nodes remains challenging. Technological advances in magnetic resonance imaging (MRI) enable to quantify diffusion and perfusion of the tumour and its surrounding tissues, which could improve diagnostic performance.

Objectives: The investigators aim to identify specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region.

Study design: a retrospective study will be set up to explore the diagnostic performance of the selected MRI parameters to differentiate between tumoural and non-tumoural cervical lymph nodes in patients with a histologically confirmed head and neck tumour ('affected group') or histologically confirmed Whartin tumour or pleomorphic adenoma of the parotid gland, without malignant transformation ('control group').

Patients will be screened for inclusion in the analysis if they had a routine preoperative multiparametric MRI, according to a standardised protocol, between the 1st of December 2016 and the 30th of September 2018. All MR images will be screened by the resident to select those patients with one or multiple clearly distinguishable metastatic cervical lymph node(s), which can be clearly correlated with the final pathology report. Other strict inclusion criteria are described in detail in the protocol.

Conditions

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Head and Neck Cancer Multiparametric MRI Cervical Lymph Node

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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affected

patients with a histologically confirmed head and neck tumour

multiparametric MRI

Intervention Type OTHER

preoperative multiparametric MRI

control

histologically confirmed Whartin tumour or pleomorphic adenoma of the parotid gland, without malignant transformation

multiparametric MRI

Intervention Type OTHER

preoperative multiparametric MRI

Interventions

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multiparametric MRI

preoperative multiparametric MRI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients that received a pretreatment multiparametric MRI according to a standardized protocol between December 2016 and December 2018
* histophatologically proven SCC in the head and neck region
* one or multiple clearly distinguishable cervical lymph node(s), that can be unambiguously correlated with the pathology report

Exclusion Criteria

* patients not fulfilling abovementioned criteria
* patients with thyroid or skin cancer
* considerable artefact on MRI
* previous surgery, irradiation or chemotherapy in the HN region

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No