Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement
NCT ID: NCT03990181
Last Updated: 2021-05-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2019-09-20
2020-08-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Meal & natural polyphenol supplement (NPPS)
A meal, labelled with stable iron isotope as ferrous sulphate, consumed with the natural polyphenol supplement
meal matrix & NPPS
Test meal consumed with the natural polyphenol supplement
Drink & natural polyphenol supplement
A drink, labelled with stable iron isotope as ferrous sulphate, consumed with the natural polyphenol supplement
no-matrix & NPPS
Test drink consumed with the natural polyphenol supplement
Meal & control supplement (CS)
A meal, labelled with stable iron isotope as ferrous sulphate, consumed with a control supplement
meal matrix & CS
Test meal consumed with the control supplement
Drink & control supplement
A drink, labelled with stable iron isotope as ferrous sulphate, consumed with a control supplement
no-matrix & CS
Test drink consumed with the control supplement
Interventions
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meal matrix & NPPS
Test meal consumed with the natural polyphenol supplement
meal matrix & CS
Test meal consumed with the control supplement
no-matrix & NPPS
Test drink consumed with the natural polyphenol supplement
no-matrix & CS
Test drink consumed with the control supplement
Eligibility Criteria
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Inclusion Criteria
* Written informed consent
* Age 18-65 y
* Not pregnant or lactating
* Body weight \< 75 kg
* Body mass index (BMI) between 18.5 and 25 kg/m2
* No acute illness/infection (self-reported)
* No metabolic or gastrointestinal disorders, eating disorders or food allergy to the ingredients of the test meal (self-reported)
* No scheduled phlebotomy throughout the study period
* The last phlebotomy will be at least 4 weeks prior first test meal administration
* No use of medications affecting iron absorption or metabolism during the study
* No intake of mineral/vitamin supplements 2 weeks before the first study day and during the study
* Participation in any other clinical study within the last 30 days
* Expected to comply with study protocol
18 Years
65 Years
ALL
Yes
Sponsors
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Instituto de Investigação em Imunologia
OTHER
Swiss Federal Institute of Technology
OTHER
Responsible Party
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Prof. Michael B. Zimmermann
Head of the Laboratory of Human Nutrition
Locations
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Porto University Hospital Center
Porto, , Portugal
Laboratory of Human Nutrition ETH Zurich
Zurich, , Switzerland
Countries
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References
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Buerkli S, Salvioni L, Koller N, Zeder C, Teles MJ, Porto G, Habermann JH, Dubach IL, Vallelian F, Frey BM, Moretti D, Baumgartner J, Zimmermann MB. The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis. Eur J Nutr. 2022 Sep;61(6):2967-2977. doi: 10.1007/s00394-022-02829-8. Epub 2022 Mar 23.
Other Identifiers
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FePPHH
Identifier Type: -
Identifier Source: org_study_id
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