Impact of Cold Ischemia on Pulmonary Endothelial Dysfunction in Ex-vivo Pulmonary Reconditioning
NCT ID: NCT03987113
Last Updated: 2020-07-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2018-11-15
2019-10-30
Brief Summary
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The ex-vivo procedure will be performed for lungs considered as limit to be directly implanted according to the national classification or in case of Maastrich 3 decision. They required a rehabilitation procedure like ex-vivo to determine their quality. Once the procedure initiated, the unused remaining liquid will be retrieved for the first gasometry usually performed. This will be the time T1 of sampling.
The unused remaining liquid will be retrieved for the gasometry of end of procedure usually performed, before the graft cooling. This will be the time T2.
The purge liquid of first lung at the declamping of the pulmonary artery will be retrieved at the time of unclamping (time T3 of sampling).
The purge liquid of the second lung at the declamping of the pulmonary artery will be retrieved with the same procedure (time T4 of sampling).
The samples will be analysed with ELISA technique. The endothelial dysfunction will be evaluated with plasma concentration of heparan sulphate, syndecan-1, endothelin-1 and i-NOS.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Interventions
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Plasma concentration analysis during and after ex-vivo pulmonary reconditioning
The pulmonary endothelial dysfunction will be evaluated with plasma concentration of heparan sulphate, syndecan-1, endothelin-1 and i-NOS.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Institut National de la Santé Et de la Recherche Médicale Rouen U1096
UNKNOWN
Hopital Foch
OTHER
Responsible Party
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Principal Investigators
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Morgan LE GUEN
Role: PRINCIPAL_INVESTIGATOR
Anaesthesia department
Locations
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Hôpital Foch
Suresnes, , France
Countries
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References
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Selim J, Wolf J, Soulie M, Sage E, Glorion M, Fessler J, Mulder P, Vasse M, Bellien J, Djerada Z, Richard V, Guen ML. Post-Ex Vivo Lung Perfusion Hypothermic Storage Limits Inflammation and Endothelial Dysfunction. J Cardiothorac Vasc Anesth. 2025 Oct;39(10):2748-2759. doi: 10.1053/j.jvca.2025.07.007. Epub 2025 Jul 8.
Other Identifiers
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2017022F
Identifier Type: -
Identifier Source: org_study_id
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