Lung Clearance Index and Lung Allograft Dysfunction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-01

Study Completion Date

2023-09-30

Brief Summary

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The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.

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Detailed Description

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This single center study consists of three parts:

1. Characterisation of the Zurich lung transplant cohort regarding CLAD status and pulmonary function impairment (cross-sectional, study part I)
2. Evaluation of test-retest reliability of LCI in 20 clinically stable lung transplant recipients during three consecutive study visits (study part II)
3. Prospective cohort study to test the ability of LCI to detect early CLAD in patients without prior CLAD (study part III)

Conditions

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Lung Transplantation Chronic Lung Allograft Dysfunction Rejection Lung Transplant

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Early detection of CLAD by Lung Clearance Index (LCI)

Lung transplant candidates without prior CLAD (evaluated in study part I) will be followed over a period of 3 years to evaluate the potential of LCI to detect early CLAD

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male and female lung transplant recipients
* Written informed consent by the participant after information about the research project

Exclusion Criteria

* Any contraindication to perform pulmonary function tests (e.g., persistent pneumothorax)
* Acute airway infection
* Chronic infection due to Burkholderia spp and nontuberculosis mykobacteria NTM

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No