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CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

NCT ID: NCT04558333

Last Updated: 2024-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-28

Study Completion Date

2024-02-28

Brief Summary

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Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.

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Detailed Description

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At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD.

Conditions

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Lung Transplant Failure and Rejection Primary Graft Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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LTx (lung transplant) patients

identification of possible biomarkers

blood and exhaled breath specimens

Intervention Type OTHER

identification of possible biomarkers

Interventions

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blood and exhaled breath specimens

identification of possible biomarkers

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* all lung transplant recipients \> 18 years signed ICF (informed consent form)

Exclusion Criteria

* none
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Antwerp

OTHER

Sponsor Role lead

Responsible Party

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Therese Lapperre

Prof. Dr. Lapperre

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Thérèse Lapperre, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Antwerp

Locations

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University Hospital Antwerp

Edegem, Antwerp, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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CLAD

Identifier Type: -

Identifier Source: org_study_id

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