The Effect of Multiple Injection of Platlet-rich Plasma in Chronic Patellar Tendinopathy
NCT ID: NCT03986372
Last Updated: 2022-03-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2/PHASE3
60 participants
INTERVENTIONAL
2019-08-20
2023-06-30
Brief Summary
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Detailed Description
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The patellar tendon suffer from repetitive microtrauma，result in reactive patellar tendinopathy. The overload tendon combining with risk factors of patellar tendinopathy will not recover timely and progress to chronic patellar tendinopathy. Hence, to reverse the progression is our aim.
According to previous studies, several nonsurgical treatment options have been proposed such as medication, eccentric exercise, corticosteroid injection, shockwave and platelet-rich plasma (PRP). Among all the options, the effect of PRP could last longer. However, the type, concentration, time and frequent of injection are still debated。Moreover, there is no study about the relationship between efficacy and the ratio and concentration of growth factor in the PRP.
The aim of this study is to understand (1) The effect of multiple injection of platlet-rich plasma in chronic patellar tendinopathy. (2) The effect of leukocyte-rich PRP in chronic patellar tendinopathy (3) Analyze the relation between efficacy of PRP and the growth factor in PRP.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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PRP injection, once
PRP injection, once
Platlet-rich plasma
Multiple Platlet-rich plasma injection.
PRP injection, twice
PRP injection, twice, 2 weeks apart
Platlet-rich plasma
Multiple Platlet-rich plasma injection.
PRP injection, 3 times
PRP injection, 3 times, 2 weeks apart
Platlet-rich plasma
Multiple Platlet-rich plasma injection.
Interventions
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Platlet-rich plasma
Multiple Platlet-rich plasma injection.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Previous knee surgery
3. Any confounding diagnosis to the knee joint
4. Arthritis
5. Rheumatoid arthritis
6. Diabetes
7. Infections of knee joint
8. NSAIDs in the 10 days before the procedure
20 Years
ALL
No
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Locations
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Taoyuan Chang Gung Memorial Hospital
Taoyuan District, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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201900117A3
Identifier Type: -
Identifier Source: org_study_id
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