Amyloidosis Typing Using Mass Spectrometry-based Proteomics: a New Accurate Tool for Difficult Typing

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-25

Study Completion Date

2021-09-08

Brief Summary

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The main objective is to establish that a new technique of amyloidosis typing by Proteomics (based on nanoLC-MS/MS mass spectrometry) allows typing in \> 90% of observations in patients whose Amyloidosis is reported to have failed typing (impossible typing, uncertain or inconsistent) with the traditional anatomopathological approach, and this in a cohort of 40 patients identified consecutively in the Department of pathological anatomy and cytology of the University Hospital of Toulouse and included prospectively.

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Detailed Description

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Conditions

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Amyloidosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Inclusion of 40 patients identified by the Department of Anatomy and pathological cytology at the University of Toulouse.

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Amylose typing

Amyloidosis typing by nanoLC-MS/MS in patients diagnosed with Amyloidosis but unable to be typed

Group Type EXPERIMENTAL

Amyloidosis typing using mass spectrometry-based proteomics

Intervention Type DIAGNOSTIC_TEST

Amyloidosis typing using nanoLC-MS/MS method

Interventions

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