Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.
NCT ID: NCT03983473
Last Updated: 2025-07-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
240 participants
INTERVENTIONAL
2021-11-16
2026-12-16
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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Crohn's disease
Patients suffering from established Crohn 's disease without spondyloarthritis
Microbiota Sequencing
virome, bacteriome, fungome NGS sequencing
Spondyloarthritis
Patients with established spondyloarthritis without Crohn 's disease
Microbiota Sequencing
virome, bacteriome, fungome NGS sequencing
Crohn + spondyloarthritis
Patients suffering from both spondyloarthritis and Crohn 's disease
Microbiota Sequencing
virome, bacteriome, fungome NGS sequencing
Healthy controls
Patients without spondyloarthritis and Crohn 's disease
Microbiota Sequencing
virome, bacteriome, fungome NGS sequencing
Interventions
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Microbiota Sequencing
virome, bacteriome, fungome NGS sequencing
Eligibility Criteria
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Inclusion Criteria
* Patients will be recruited according to 3 groups:
* Patients with Crohn's disease and axial spondyloarthritis according to the criteria below.
* Patients with Crohn's disease (MC patients) with a diagnosis established according to clinical, biological criteria, radiological, endoscopic and / or histological studies for 3 months. With diagnosis of exclusion of a spondyloarthritis on criteria ASAS and / or New York modified.
* Patients with axial spondyloarthritis (SpA patients) with a diagnosis based on modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease.
* Patient with the ability to give free and express informed consent.
Exclusion Criteria
* Taking antibiotics or colon preparation for colonoscopy within 8 weeks before stool collection (Temporary contraindication = removal possible before colic or first bowel preparation after the start of colonic preparation).
* Ostomy at the time of sampling
* BMI\> 30
* extreme diet
* unbalanced diabetes
* Pregnant woman
* Patient under guardianship, under curatorship or under the protection of justice Contacts/Locations Central Contact
18 Years
ALL
Yes
Sponsors
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Centre Hospitalier Régional Metz-Thionville
OTHER
University Hospital, Strasbourg, France
OTHER
Saint Antoine University Hospital
OTHER
Central Hospital, Nancy, France
OTHER
Responsible Party
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Dr Laurent PEYRIN-BIROULET
Professor
Locations
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Central Hospital
Nancy, Lorraine, France
Saint Antoine Hospital
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Laurent MD PEYRIN-BIROULET, PhD
Role: primary
Harry SOKOL, MD, PhD
Role: primary
Jérémie SELLAM, MD, PhD
Role: backup
Other Identifiers
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2020-A02298-31
Identifier Type: -
Identifier Source: org_study_id
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