Microflora and Metabolomics of Crohn's Disease Patients

NCT ID: NCT04965584

Last Updated: 2021-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-01

Study Completion Date

2022-07-31

Brief Summary

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The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.

Detailed Description

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This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.

Conditions

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Crohn Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Active Crohn's disease group

Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological manifestations and histological features were recruited, and patients with CDAI score ≥ 150 were included in this group.

No interventions assigned to this group

Crohn's disease remission group

Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological features and histological features were recruited, and patients with CDAI score \< 150 were included in this group.

No interventions assigned to this group

Healthy control group

Normal healthy people were randomly recruited as the control group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. individuals who were clear and signed the informed consent.
2. Male and female.

Exclusion Criteria

1. Any one who can not provide accurate information.
2. Any one who denies the study.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai 10th People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Huanlong Qin

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shanghai 10th People's Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Central Contacts

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Kai Xia, MM

Role: CONTACT

13588251107

Renyuan Gao, MD

Role: CONTACT

15601675695

Facility Contacts

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Kai Xia, MM

Role: primary

13588251107

References

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Xia K, Gao R, Wu X, Sun J, Wan J, Wu T, Fichna J, Yin L, Chen C. Characterization of Specific Signatures of the Oral Cavity, Sputum, and Ileum Microbiota in Patients With Crohn's Disease. Front Cell Infect Microbiol. 2022 Apr 13;12:864944. doi: 10.3389/fcimb.2022.864944. eCollection 2022.

Reference Type DERIVED
PMID: 35493739 (View on PubMed)

Other Identifiers

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SHSYXK

Identifier Type: -

Identifier Source: org_study_id

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