Characteristics and Inflammatory Markers in Children with Eosinophilic Esophagitis (EoE)
NCT ID: NCT03980886
Last Updated: 2024-11-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1500 participants
OBSERVATIONAL
2019-02-11
2028-12-17
Brief Summary
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Detailed Description
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Medical information including clinical symptoms, endoscopy, histopathology, medical and surgical history, lab and imaging findings, are entered into a UCSD database at each clinic or endoscopy visit. Blood and biopsy specimens are procured and utilized for analysis of inflammatory molecules and for isolation of structural cells. This protocol continues our clinical database and sample collection in children with EoE. The database provides a cohort of EoE patients for studies of natural history, therapeutic response, and disease progression. In a relatively new disease of increasing incidence, these studies will provide information on disease progression and the clinical characteristics of patients who have varying disease phenotypes as well as the associations between clinical phenotypes, molecular changes, and disease course. The procurement and storage of tissue, cells, and serum samples provides a repository for studies of EoE-related molecules and peripheral markers in clinically phenotyped patients. In addition, the study of these esophageal cells will provide an in vitro model system for assessing the molecular mechanisms of disease pathogenesis in EoE.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications)
* Present with food impaction
* Present with esophageal stricture
* Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings
Exclusion Criteria
1 Year
65 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
University of California, San Diego
OTHER
Responsible Party
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Seema Aceves
Professor, Pediatrics and Medicine
Locations
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Rady Children's Hospital San Diego
San Diego, California, United States
Countries
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Central Contacts
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Facility Contacts
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Seema Aceves, MD.PhD
Role: backup
Ranjan Dohil, MD
Role: backup
Jun Mo, MD
Role: backup
Cathleen Collins, MD
Role: backup
Other Identifiers
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