Immune Dysfunction in Allergic Asthma

NCT ID: NCT00189228

Last Updated: 2019-09-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2008-06-30

Brief Summary

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We are using anti-IgE to investigate the role of pulmonary mast cells in asthma.

Detailed Description

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Subjects with mild allergic asthma are examined before, immediately after and 2 months after a course of treatment with anti-IgE. The following are examined: Allergen skin tests, allergen induced asthma, peripheral blood basophils, pulmonary bronchial mucosal mast cells.

Conditions

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Asthma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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xolair

This is a single arm, parallel study examining differences of therapeutic outcomes of Xolair. Xolair is being examined as an intervention that might change the outcome of immunization.

Group Type EXPERIMENTAL

Xolair

Intervention Type DRUG

Patients are administered Xolair

Interventions

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Xolair

Patients are administered Xolair

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Mild asthma, adults -

Exclusion Criteria

children. on inhaled or systemic steroids

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

University of New Mexico

OTHER

Sponsor Role lead

Responsible Party

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Mark Schuyler

Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mark Schuyler, MD

Role: STUDY_DIRECTOR

UNM HSC

Locations

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UNM HSC

Albuquerque, New Mexico, United States

Site Status

Countries

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United States

Other Identifiers

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R01HL044253

Identifier Type: NIH

Identifier Source: secondary_id

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UNMSCOR

Identifier Type: -

Identifier Source: org_study_id

NCT00201097

Identifier Type: -

Identifier Source: nct_alias

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