Change in Tongue Strength and Fatigue After Upper Airway Stimulation Therapy

NCT ID: NCT03980158

Last Updated: 2019-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

103 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-01

Study Completion Date

2018-11-16

Brief Summary

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Upper airway stimulation (UAS) is an effective surgical alternative for patients with obstructive sleep apnea (OSA) who fail continuous positive airway pressure (CPAP) therapy. This stimulation could lead to alterations in tongue strength and fatigability which could alter treatment outcome. The aim of the study is to investigate if UAS alters tongue strength and fatigability.

Detailed Description

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Conditions

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Obstructive Sleep Apnea of Adult

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Upper airway stimulation group

No interventions assigned to this group

OSA group with conservative / no treatment

No interventions assigned to this group

Test group without OSA

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 18 years old or older
* upper airway stimulation group: Upper airway stimulation system implanted at least 4 weeks ago
* OSA group: OSA confirmed by 18-channel inpatient overnight polysomnography (PSG)
* test group: No medical history for OSA and Epworth Sleepiness Scale (ESS) below 11

Exclusion Criteria

* history of a neuromuscular disorder
* previous tongue surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Technical University of Munich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Ear Nose Throat

Munich, Bavaria, Germany

Site Status

Countries

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Germany

References

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Wirth M, Unterhuber D, von Meyer F, Hofauer B, Ott A, Edenharter G, Eckert DJ, Heiser C. Hypoglossal nerve stimulation therapy does not alter tongue protrusion strength and fatigability in obstructive sleep apnea. J Clin Sleep Med. 2020 Feb 15;16(2):285-292. doi: 10.5664/jcsm.8184. Epub 2020 Jan 13.

Reference Type DERIVED
PMID: 31992396 (View on PubMed)

Other Identifiers

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425/17S

Identifier Type: -

Identifier Source: org_study_id

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