Retinal Vascular Network and Obstructive Sleep Apnea

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

166 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-06

Study Completion Date

2024-08-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Obstructive sleep apnea syndrome (OSA) is thought to lead to systemic vascular lesions that may be preceded by early microvascular lesions in the eyes and in particular in the retina. The improvement of ophthalmological imaging techniques by OCTangiography allows a precise non-invasive study of the retinal microvascular network. This new rapid and non-invasive retinal imaging tool could reveal micro-vascular lesions related to OSA. To the investigator's knowledge, this would be the first OCT-angiography description of a cohort of patients with OSA. If these results are confirmed, it would be interesting to study the correlation between these micro-vascular lesions and the cardiovascular risk of his patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Retinal Vein Occlusion and Obstructive Sleep Apnea: A Case Control Study

NCT04011358

Retinal Vein Occlusion Obstructive Sleep Apnea

WITHDRAWN NA

Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators

NCT04648618

Diabetic Macular Edema Obstructive Sleep Apnea Diabetic Retinopathy

UNKNOWN

Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion

NCT01291862

Retinal Vascular Occlusion

UNKNOWN NA

Evaluation of Obstructive Sleep Apnea With Long Range 3D Endoscopic Fourier Domain Optical Coherence Tomography (FDOCT)

NCT01485497

Sleep Apnea

WITHDRAWN PHASE1

Impact Of Closure Of Patent Foramen Ovale On Apnoea-Hypopnoea-Index, Nocturnal Hypoxemia And Systemic Vascular Function In Patients With Obstructive Sleep Apnoea

NCT01780207

Obstructive Sleep Apnea

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obstructive Sleep Apnea Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients

Patients referred for polysomnography diagnosis of obstructive sleep apnea syndrome

complete ophthalmological examination

Intervention Type OTHER

collection:

* ophthalmological history and current treatments
* occular tension measurement
* measurement of visual acuity (Snellen chart)
* Axial length measurement
* Photograph of the posterior segment of the eye
* 3x3 and 6x6 macular and papillary OCT angiography

Controls

Person without obstructive sleep apnea syndrome

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

complete ophthalmological examination

collection:

* ophthalmological history and current treatments
* occular tension measurement
* measurement of visual acuity (Snellen chart)
* Axial length measurement
* Photograph of the posterior segment of the eye
* 3x3 and 6x6 macular and papillary OCT angiography

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* person who has given oral consent
* person who can be followed throughout the study
* adult

Patient group:

\- Patient seen in sleep apnea screening consultation by a pulmonologist and referred for polysomnography diagnosis of OSA

Control Group:

\- Person initially without obstructive sleep apnea syndrome

Exclusion Criteria

* a person who is not affiliated to or not a beneficiary of the national health insurance system
* person subject to a measure of legal protection (curatorship, guardianship)
* person subject to a safeguard of justice
* pregnant, parturient or breastfeeding woman
* adult incapable or unable to consent
* person with a contraindication to Tropicamide or Neosynephrine
* person with a history of eye disease affecting ocular circulation (examples: acute anterior ischemic optic neuropathy, retinal central artery occlusion, retinal central vein occlusion, diabetic retinopathy, glaucoma, uncontrolled hypertonia, AMD, severe myopia...)

Control Group:

* person with a history of chronic lung problems (e.g. COPD, chronic respiratory failure, etc.)
* person with at least one of the following risk factors for obstructive sleep apnea syndrome:

* Obesity with IMC≥30
* Alcohol consumption \> 3 glasses per day

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes