NeuMoDx PrEDiCTiNG Study Evaluation Plan

NCT ID: NCT03970850

Last Updated: 2020-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4017 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-22

Study Completion Date

2020-02-25

Brief Summary

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This investigational study will be conducted to evaluate the performance of the NeuMoDx™ CT/NG Assay on the NeuMoDx™ 288 Molecular System and NeuMoDx™ 96 Molecular System (collectively referred to as NeuMoDx™ CT/NG Assay test system).

Detailed Description

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Clinical performance characteristics of the NeuMoDx CT/NG Assay on NeuMoDx™ 288 Molecular System and NeuMoDx™ 96 Molecular System will be evaluated in a multi-center, prospective, sampling study by comparing the diagnoses made by the NeuMoDx™ CT/NG Assay to Patient Infected Status (PIS) as the reference standard.

Prospectively collected urine and swab specimens from individual subjects will be tested using the NeuMoDx™ CT/NG Assay at one of the three NeuMoDx testing sites. Subjects' PIS for CT and PIS for NG will be determined by a central laboratory using FDA-cleared, legally marketed CT/NG combo assays on pre-specified sample matrices according to the PIS determination algorithms.

Conditions

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Chlamydia Trachomatis Infection Neisseria Gonorrheae Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Multi-arm - Symptomatic and Asymptomatic Males

Arm 1 - Urine from males subjects

Group Type ACTIVE_COMPARATOR

NeuMoDx CT/NG Assay

Intervention Type DIAGNOSTIC_TEST

NeuMoDx CT/NG Assay as implemented on NeuMoDx 288 Molecular System and NeuMoDx 96 Molecular System

Multi-arm - Symptomatic and Asymptomatic Females

Arm 2 - Endocervical, self-collected (in the clinical setting) and physician-collected vaginal swabs and urine from female subjects

Group Type ACTIVE_COMPARATOR

NeuMoDx CT/NG Assay

Intervention Type DIAGNOSTIC_TEST

NeuMoDx CT/NG Assay as implemented on NeuMoDx 288 Molecular System and NeuMoDx 96 Molecular System

Multi-arm - FDA cleared NAATs (Comparator)

Arm 3 - Comparator (for females - vaginal and urine NAATs and for males - 3 urine NAATs)

Group Type ACTIVE_COMPARATOR

FDA-cleared NAATs

Intervention Type DIAGNOSTIC_TEST

Testing swabs and urine specimen from both male and female subjects on the FDA-cleared NAATs

Interventions

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NeuMoDx CT/NG Assay

NeuMoDx CT/NG Assay as implemented on NeuMoDx 288 Molecular System and NeuMoDx 96 Molecular System

Intervention Type DIAGNOSTIC_TEST

FDA-cleared NAATs

Testing swabs and urine specimen from both male and female subjects on the FDA-cleared NAATs

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Male and female subjects of at least 14 years of age or older.
2. Subject must be able and willing to provide informed consent. The use of a 'surrogate' or 'Legally Authorized Representative' is allowed and shall follow the site's standard procedures, under which the clinical investigation will be conducted.
3. Subjects undergoing a routine pelvic examination, subjects eligible for screening evaluations for possible STDs and/or subjects known to be partners with a person with a confirmed or suspected STD.
4. Subject is willing to provide all required specimens.

Exclusion Criteria

1. Female subject reports that she had a hysterectomy.
2. Subject self-reports use of antibiotics within 28 days of study enrollment.
Minimum Eligible Age

14 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NAMSA

OTHER

Sponsor Role collaborator

NeuMoDx Molecular, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status

Healthcare Clinical Date, Inc. (Segal Trials)

North Miami, Florida, United States

Site Status

Planned Parenthood - Southwest and Central Florida

Orlando, Florida, United States

Site Status

Planned Parenthood - Southwest and Central Florida

Tampa, Florida, United States

Site Status

Indiana University (IU)

Indianapolis, Indiana, United States

Site Status

LSU Health Science

New Orleans, Louisiana, United States

Site Status

NeuMoDx Molecular, Inc.

Ann Arbor, Michigan, United States

Site Status

Henry Ford Health System (HFHS)

Detroit, Michigan, United States

Site Status

Planned Parenthood - Northern, Central and Southern New Jersey

Elizabeth, New Jersey, United States

Site Status

Planned Parenthood - Northern, Central and Southern New Jersey

Newton, New Jersey, United States

Site Status

Planned Parenthood - Northern, Central and Southern New Jersey

Riverside Park, New Jersey, United States

Site Status

TriCore Reference Labs

Albuquerque, New Mexico, United States

Site Status

MetroHealth Medical Center

Cleveland, Ohio, United States

Site Status

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States

Site Status

Planned Parenthood - Gulf Coast

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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CTNG-01-18NMD

Identifier Type: -

Identifier Source: org_study_id

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