Behavioral Addictions and Related NeuroCOgnitive Aspects

NCT ID: NCT03967418

Last Updated: 2025-07-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 116 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-10-28
• Study Completion Date: 2025-06-26

Brief Summary

Improving knowledge about behavioural addictions is a real public health issue. The etiopathogenic model of behavioural addictions is multifactorial, with various risk and vulnerability factors, involved in the initiation and maintenance of the disorders. Among these factors, neurocognitive alterations associated with behavioural addictions has recently aroused interest among researchers.

To our knowledge, there is no work wich compared several behavioural addictions with each other on a neurocognitive level. Moreover, neurocognitive data concerning certain behavioural addictions (such as sexual addiction) is almost non-existent. However, understanding the neurocognitive profiles of these patients would allow the investigators, on the one hand, to reinforce the existing literature and improve our understanding of the global process of addiction, and on the other hand, to propose alternative approaches to its management, taking into account the neurocognitive difficulties of the patients.

The investigators therefore propose to explore the neurocognitive alterations of patients suffering from several behavioural addiction (sexual addiction and eating disorders with bulimia episodes), by comparing them with each other, to matched healthy control groups and to a recognized behavioural addiction (gambling disorder; data from the BANCO study - NCT03202290).

Conditions

Behavioral Addiction

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Patients with behavioral addictions

Patients suffering from behavioural addiction (sexual addiction and eating disorders with bulimia episodes) will be recruited

Group Type: OTHER

Cognitive and clinical assessment

Intervention Type: BEHAVIORAL

The content of the assessment will be the same for all subjects and will consist of a cognitive assessment (neurocognition, social cognition, metacognition, emotional reactivity) and a clinical assessment (impulsivity, personality, psychiatric and addictive comorbidities)

Healthy volunteers

Healthy volunteers will be matched on gender, age and education level to patients

Group Type: OTHER

Cognitive and clinical assessment

Intervention Type: BEHAVIORAL

The content of the assessment will be the same for all subjects and will consist of a cognitive assessment (neurocognition, social cognition, metacognition, emotional reactivity) and a clinical assessment (impulsivity, personality, psychiatric and addictive comorbidities)

Interventions

Cognitive and clinical assessment

The content of the assessment will be the same for all subjects and will consist of a cognitive assessment (neurocognition, social cognition, metacognition, emotional reactivity) and a clinical assessment (impulsivity, personality, psychiatric and addictive comorbidities)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• More than 15 years and 3 months old
• Mastering the French language
• Social Security Affiliates
• Having given consent
• Correct level of vision allowing the reading of instructions, the distinction of shapes and colours and the understanding of shapes and images presented in cognitive tasks (subjectively attested by the patient)
• Correct hearing level, allowing a good understanding of the sounds presented (subjectively attested by the patient and the assessor at the first contact for eligibility)

• Suffering from one of the behavioural addiction explored
• Beginning treatment in the Addictology department of the University Hospital of Nantes

• Free from the explored behavioural addictions

Exclusion Criteria

• Current and not stabilized psychiatric and addictive disorders (mood disorders, anxiety disorders and substance-use disorders except nicotine, lifetime psychotic syndrome), diagnosed by the MINI and after consultation with the clinician,
• Non stabilized endocrine disorders
• Neurological disorders (such as head trauma, neurodegenerative diseases, unbalanced epilepsy, mental retardation, etc.),
• Taking a psychotropic treatment wich is not stabilized for at least 2 weeks,
• Consumption of a psychoactive substance - other than nicotine - within the 12 hours prior to the assessment,
• Color blindness
• Cardiac problems self-reported by the patient, in order to avoid bias in the measurement of cardiac parameters,
• Electrical implants as declared by the participant (to avoid measurement artifacts)
• Having benefited from current or past cognitive remediation program
• Reporting being pregnant or breastfeeding
• Current participation or in the past month in a pharmacological research protocol
• Presenting difficulties for reading or writing French
• Being under guardianship
• With significant cognitive impairment not compatible with de cognitive assessment

• Suffering from one of the behavioural addiction explored

• Minimum Eligible Age: 15 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Nantes University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Marie GRALL BRONNEC, Pr

Role: PRINCIPAL_INVESTIGATOR

Nantes University Hospital

Locations

CHU de Nantes

Nantes, , France

Countries

France

References

Hurel E, Grall-Bronnec M, Thiabaud E, Saillard A, Hardouin JB, Challet-Bouju G. A Case-Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols. Neuropsychiatr Dis Treat. 2021 Jul 20;17:2369-2386. doi: 10.2147/NDT.S292490. eCollection 2021.

Reference Type: DERIVED

PMID: 34321880 (View on PubMed)

Other Identifiers

RC19_0177

Identifier Type: -

Identifier Source: org_study_id