A Phase 2, 12-Week, Double-Blind, Efficacy and Safety of GX-G6 in Patients With Uncontrolled Type 2 Diabetes Mellitus

NCT ID: NCT03962010

Last Updated: 2019-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-06-01

Study Completion Date

2022-07-01

Brief Summary

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GX-G6-002 is a Phase 2, 12-week, randomized, parallel group, multi-centre, double blind, placebo-controlled and an open-label active comparator study.

Detailed Description

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This study aims to establish the dose-response relationship of 4 dose cohorts of GX-G6 compared with double-blind placebo. These treatment cohorts will also be compared with open-label active control.

Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Dose level 1

Group Type EXPERIMENTAL

GX-G6

Intervention Type DRUG

long acting anti-diabetic drug

Dose level 2

Group Type EXPERIMENTAL

GX-G6

Intervention Type DRUG

long acting anti-diabetic drug

Dose level 3

Group Type EXPERIMENTAL

GX-G6

Intervention Type DRUG

long acting anti-diabetic drug

Dose level 4

Group Type EXPERIMENTAL

GX-G6

Intervention Type DRUG

long acting anti-diabetic drug

Placebo

Group Type PLACEBO_COMPARATOR

Control

Intervention Type DRUG

Control

Dulaglutide

Group Type ACTIVE_COMPARATOR

Control

Intervention Type DRUG

Control

Interventions

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GX-G6

long acting anti-diabetic drug

Intervention Type DRUG

Control

Control

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Diagnosis of T2DM ≥ 6 months prior to screening
2. HbA1c level of 7-10% (inclusive)

Exclusion Criteria

1. Have known type 1 diabetes mellitus (T1DM)
2. History of severe hypoglycaemia defined as ≥ 2 episodes of severe hypoglycaemia within 6 months prior to screening
3. Have had ≥ 2 episodes of ketoacidosis or hyperosmolar state/coma requiring hospitalization in the 6 months prior to screening
4. Has fasting serum TG ≥ 500 mg/dL or 9 mmol/L at screening.
5. Patients receiving lipid-lowering therapy must have been on the same dose of therapy for the past three months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Genexine, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Yun Jung Choi, Ph.D

Role: CONTACT

82 31 628 3210

Other Identifiers

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GX-G6-002

Identifier Type: -

Identifier Source: org_study_id

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