PREVENTION-ACHD Risk Score

NCT ID: NCT03957824

Last Updated: 2019-05-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 783 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-01-01
• Study Completion Date: 2018-06-30

Brief Summary

Sudden cardiac death (SCD) is one of the major causes of mortality in adults with congenital heart disease (ACHD). Risk stratification for sudden cardiac death in this patient group is challenging and at the current moment there are no clear guidelines on implantable cardioverter-defibrillator (ICD) implantation for primary prevention of SCD in this young patient population. The reason for this is the fact that this is a heterogenous group of patients and SCD is a relatively rare event. Because of this there have been no prospective studies on SCD in ACHD. However, multiple retrospective studies on ICD implantation in ACHD have shown that this treatment does appear to be effective. Researchers from the Academic Medical Center have identified several risk factors for sudden cardiac death. A risk score was created using this data, which has been validated in an internal and external cohort in a retrospective setting. The design of this study, including the conception of the risk score, its calculation method and validation will be published in an international scientific peer-reviewed journal.

The hypothesis of this study is that the risk score accurately predicts the risk of sudden cardiac death.

Conditions

Death, Sudden, Cardiac; Ventricular Fibrillation; Ventricular Tachycardia; Congenital Heart Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

PREVENTION-ACHD risk score

The predicted risk of sudden cardiac death according to a risk score will be tested by the actual rate of sudden cardiac death

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• adult (≥18 years old) patient with a diagnosis of a congenital heart defect.

Exclusion Criteria

• Patients of whom follow up is not possible, e.g. no permanent home address, living outside of or expecting to move out of the area wherein travelling to the investigating hospital outpatient clinic is possible.

• Patients with documented sustained ventricular tachycardia or ventricular fibrillation.
• Patients for whom the risk is not calculable because of a congenital heart disease diagnose not represented in the risk score.
• Patients for whom the risk score is not calculable because of missing data
• Patients with recent (<3 months ago) myocardial infarction.
• Patients in whom the high SCD-risk status depends on an impaired ejection fraction that is expected to improve, e.g. due to tachycardiomyopathy.
• Patients with a guideline defined contraindication for ICD implantation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

Sponsor Role: lead

Responsible Party

Joris R. de Groot

Professor of Cardiac Electrophysiology and Atrial Fibrillation

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Joris R de Groot, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Academic Medical Center - University of Amsterdam (AMC-UvA)

References

Vehmeijer JT, Koyak Z, Zwinderman AH, Harris L, Peinado R, Oechslin EN, Silversides CK, Bouma BJ, Budts W, van Gelder IC, Oliver JM, Mulder BJM, de Groot JR. PREVENTION-ACHD: PRospEctiVE study on implaNTable cardioverter-defibrillator therapy and suddeN cardiac death in Adults with Congenital Heart Disease; Rationale and Design. Neth Heart J. 2019 Oct;27(10):474-479. doi: 10.1007/s12471-019-1297-3.

Reference Type: DERIVED

PMID: 31270738 (View on PubMed)

Other Identifiers

2014_248#C20141535

Identifier Type: -

Identifier Source: org_study_id