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Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

NCT ID: NCT03933930

Last Updated: 2020-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-06

Study Completion Date

2021-05-15

Brief Summary

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Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.

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Detailed Description

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Conditions

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Organ Failure, Multiple

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Lactate-directed therapy

Group Type EXPERIMENTAL

Lactate-directed therapy

Intervention Type OTHER

If the lactate level elevates, we transfuse pRBC to increase Hct\>30%. If Hct \>30%, dopamine infusion starts.

Goal-directed therapy

Intervention Type OTHER

If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.

Goal-directed therapy

Group Type EXPERIMENTAL

Goal-directed therapy

Intervention Type OTHER

If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.

Interventions

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Lactate-directed therapy

If the lactate level elevates, we transfuse pRBC to increase Hct\>30%. If Hct \>30%, dopamine infusion starts.

Intervention Type OTHER

Goal-directed therapy

If SVV\>15%, transfuse lactate ringer/normal saline alternatively to keep SVV\<15%.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients receiving hyperthermic intraperitoneal chemotherapy

Exclusion Criteria

* Unable to set arterial line Severe liver or renal disease Severe heart disease Unconscious patients
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Medical University WanFang Hospital

OTHER

Sponsor Role lead

Responsible Party

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anchihhsu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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N201803039

Identifier Type: -

Identifier Source: org_study_id

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