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Circulatory Function in Laparoscopic Radical Cystectomy for Bladder Cancer

NCT ID: NCT03892031

Last Updated: 2022-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

186 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2019-12-31

Brief Summary

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To optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(LPC) for bladder cancer through observation of perioperative changes of Brain Natriuretic Peptide(BNP), stroke volume variation(SVV), central venous pressure(CVP) and the use of transthoracic echocardiography(TTE).

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Detailed Description

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Long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer influence perioperative circulatory function, resulting in a series of pathophysiological changes. BNP is of high sensitivity and specificity in the evaluation of cardiac function. SVV and CVP are dynamic and static indices to predict fluid responsiveness. TTE is a good indicator of volume and cardiac function.Thus, we conducted the trial to assess the perioperative circulatory function in patients undergoing LPC. We hypothesized that long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer would increase perioperative blood volume and influence cardiac function.

Conditions

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Circulatory Function Laparoscopic Radical Cystectomy for Bladder Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* undergoing laparoscopic radical cystectomy for bladder cancer
* ASA I-II

Exclusion Criteria

* Cardiac insufficiency
* Hepatic insufficiency
* Renal insufficiency
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RenJi Hospital

OTHER

Sponsor Role lead

Responsible Party

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DAN HUANG

Principal Investigator, clinical attending in anesthesia department

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jie Chen, MS

Role: STUDY_CHAIR

Renji Hospital, School of Medicine, Shanghai Jiaotong University, China

Locations

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Renji Hospital, School of Medicine, Shanghai Jiaotong University, China

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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Circulatory function in LRC

Identifier Type: -

Identifier Source: org_study_id

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