Proteomics Research of Osteosarcoma

NCT ID: NCT03932058

Last Updated: 2019-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-01

Study Completion Date

2020-09-01

Brief Summary

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Retrospectively collected 400 cases of clinical data and pathological paraffin specimens of osteosarcoma, chondrosarcoma (control) and endogenous chondroma (control) in our hospital from 2008 to 2014, combined with high-pressure cycle-satellite scanning mass spectrometry (PCT-SWATH) Molecular typing of osteosarcoma and prediction of targeted therapy, the establishment of a new molecular classification based on proteomics for osteosarcoma to predict the chemotherapy response and recurrence risk of osteosarcoma. Clinical osteosarcoma patients include as many types as possible: pre-chemotherapy, post-chemotherapy, recurrence, and metastasis. The study did not involve vulnerable groups, and it was taken as a postoperative wax specimen for patients, which had no health, life and other effects on patients. Study application exemption from informed consent.

Detailed Description

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Conditions

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Osteosarcoma Proteomics

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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osteosarcoma

Chemotherapy

Intervention Type DRUG

all osteosarcoma patients will give regular chemotherapy for osteosarcoma, the protocol is the same as Methotrexate+Doxorubicin+Cisplatin.

chondrosarcoma

No interventions assigned to this group

enchondroma

No interventions assigned to this group

Interventions

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Chemotherapy

all osteosarcoma patients will give regular chemotherapy for osteosarcoma, the protocol is the same as Methotrexate+Doxorubicin+Cisplatin.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* all osteosarcoma patients in our hospital
* received Methotrexate+Doxorubicin+Cisplatin protocol chemotherapy

Exclusion Criteria

* non-chemotherapy patients
* bio-specimen not completed
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Zhaoming Ye

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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zhaoming Ye, Prof.

Role: PRINCIPAL_INVESTIGATOR

2nd Affiliated Hospital Of Zhejiang University

Locations

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2nd Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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zhan Wang, Dr.

Role: CONTACT

+8618758586092

Xiaobo Yan

Role: CONTACT

+8613588153306

Facility Contacts

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Xiaobo Yan

Role: primary

13588153306

Other Identifiers

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PR-OS-001

Identifier Type: -

Identifier Source: org_study_id

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