Effect of Self Assembling Peptide on White Spot Lesion

NCT ID: NCT03930927

Last Updated: 2019-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

EARLY_PHASE1

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-01

Study Completion Date

2021-03-01

Brief Summary

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During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?

Detailed Description

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Conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . Remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. It is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice.

Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.

Conditions

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White Spot Lesion of Tooth

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Self Assembling peptide

intervention

Group Type EXPERIMENTAL

Self Assembling peptide

Intervention Type DRUG

enamel regeneration

remineralizing agent

Intervention Type DRUG

enamel regeneration

Fluoride

Comparator

Group Type EXPERIMENTAL

Self Assembling peptide

Intervention Type DRUG

enamel regeneration

remineralizing agent

Intervention Type DRUG

enamel regeneration

Interventions

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Self Assembling peptide

enamel regeneration

Intervention Type DRUG

remineralizing agent

enamel regeneration

Intervention Type DRUG

Other Intervention Names

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Curodont floride

Eligibility Criteria

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Inclusion Criteria

* Patients with post orthodontic white spot lesion.
* Patients with good oral hygiene.
* Patients with good general health.
* Cooperative patients.
* Subjects who signed the informed consent.

Exclusion Criteria

* Patients with tetracycline pigmentation and dental fluorosis.
* Enamel cavitation.
* Disable patient.
* patient with any systemic disease or severe medical complications.
Minimum Eligible Age

12 Years

Maximum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Raneen Ahmed

OTHER

Sponsor Role lead

Responsible Party

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Raneen Ahmed

assistant lecturer

Responsibility Role SPONSOR_INVESTIGATOR

Central Contacts

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raneen ahmed gohar, Assistant lecturer

Role: CONTACT

(002)01007331552

sherine hafez ibrahim, Assistant lecturer

Role: CONTACT

(002)01099296591

Other Identifiers

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1998

Identifier Type: -

Identifier Source: org_study_id

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