Compare the Efficacy of the Remineralization Agents on the White Enamel Lesions
NCT ID: NCT02341872
Last Updated: 2016-07-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2013-08-31
2016-07-31
Brief Summary
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Detailed Description
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Fluoride varnish or polipeptide containing agents alone or combination using effects on remineralization, esthetic and bacterial counts will be evaluated with Quantitive Light Fluorescence , Diagnodent (Cavo-Diagnodent), Spectrophotometer (Vita Easy Shade) devices and microbiological assessment at laboratory.
The investigators will choose and include in our study that who come to the Ege University Faculty of Dentistry pediatric department, between 10-18 years olds, healthy and have one or more white spot lesions on her/his permanent teeth.
32 volunteer who have inclusion criteria will be put into pratice. 32 volunteer divided into 4 groups for different applications. We will tell each volunteer that they must brush their teeth twice a day with fluoride dentifrice ( the investigators will give them 1400 ppm fluoride containing fluoride dentifrice)
1. Group: Control group ( The investigators won't do any application , the oral hygiene konwledge will be given only.)
2. Group: Fluoride + Calcium (TCP) (The investigators will do fluoride+ calcium varnish( Clinpro white varnish) application on white spot lesions)
3. Group: Polipeptide solution (The investigators will do polipeptide ( Curodont repair) solution application on white spot lesions)
4. Group: \[Fluoride + calcium varnish\] + polipeptide solution combination ( The investigators will do polipeptide ( Curodont repair) solution and fluoride + calcium varnish (Clinpro white varnish) application on white spot lesions) First day,the investigators will collect stimulated saliva from each volunteer before any application. Saliva samples will transport to the microbiology laboratory. After any application 6 weeks, 3 months and 6 months later we will collect stimulated saliva again for microbiological assessment.
Nyvad Caries Diagnostic Criteria , ICDAS indexes will be used to make the follow-up of lesions at baseline and 6 months after the application. Plaque index (Silness \& Löe , 1964) and bleeding index (Ainamo\&Bay ,1976) will be used to assess oral hygiene every visit.
The investigators will use QLF,Diagnodent devices will be used at beginning for evaluate the demineralization level and after applications 6 weeks, 3 months and 6 months later used for evaluate the remineralization level. In addition for determine about esthetic results the investigators will use spectrophotometer (Vita Easy Shade) device at beginning, 6 weeks, 3 months and 6 months later.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Control
The investigators won't do any application , the oral hygiene konwledge will be given only.
No interventions assigned to this group
Fluoride + Calcium varnish
The investigators will do fluoride+ calcium varnish( Clinpro White Varnish) application on white spot lesions.
Clinpro White Varnish (fluoride + calcium varnish)
Clinpro White Varnish will be applied to the teeth with brush.
Polipeptide solution
The investigators will do polipeptide ( Curodont Repair) solution application on white spot lesions.
Curodont Repair
Curodont Repair solution be applied to the teeth in the form of drops
Fluoride + calcium + polipeptide
The investigators will do polipeptide ( Curodont Repair) solution and fluoride + calcium varnish (Clinpro White Varnish) application on white spot lesions.
Clinpro White Varnish (fluoride + calcium varnish)
Clinpro White Varnish will be applied to the teeth with brush.
Curodont Repair
Curodont Repair solution be applied to the teeth in the form of drops
Interventions
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Clinpro White Varnish (fluoride + calcium varnish)
Clinpro White Varnish will be applied to the teeth with brush.
Curodont Repair
Curodont Repair solution be applied to the teeth in the form of drops
Eligibility Criteria
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Inclusion Criteria
* healthy
* have one or more white spot lesions on her/his permanent teeth
Exclusion Criteria
* unsuitable age
* don't give approval for this study
10 Years
18 Years
ALL
Yes
Sponsors
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Ege University
OTHER
Responsible Party
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Ecem Ergin
Dt.
Principal Investigators
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Ecem Ergin
Role: PRINCIPAL_INVESTIGATOR
Ege University
Ece Eden
Role: STUDY_DIRECTOR
Ege University
Mustafa Ateş
Role: STUDY_CHAIR
Ege University
Locations
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Ege University School of Dentistry Department of Pedodontics
Izmir, İzmir, Turkey (Türkiye)
Countries
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References
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Oliveira GM, Ritter AV, Heymann HO, Swift E Jr, Donovan T, Brock G, Wright T. Remineralization effect of CPP-ACP and fluoride for white spot lesions in vitro. J Dent. 2014 Dec;42(12):1592-602. doi: 10.1016/j.jdent.2014.09.004. Epub 2014 Sep 23.
Lelli M, Putignano A, Marchetti M, Foltran I, Mangani F, Procaccini M, Roveri N, Orsini G. Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study. Front Physiol. 2014 Sep 5;5:333. doi: 10.3389/fphys.2014.00333. eCollection 2014.
Kirkham J, Firth A, Vernals D, Boden N, Robinson C, Shore RC, Brookes SJ, Aggeli A. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007 May;86(5):426-30. doi: 10.1177/154405910708600507.
Beerens MW, Boekitwetan F, van der Veen MH, ten Cate JM. White spot lesions after orthodontic treatment assessed by clinical photographs and by quantitative light-induced fluorescence imaging; a retrospective study. Acta Odontol Scand. 2015 Aug;73(6):441-6. doi: 10.3109/00016357.2014.980846. Epub 2014 Nov 25.
Mehta R, Nandlal B, Prashanth S. Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous calcium phosphate fluoride on artificial enamel white spot lesion: an in vitro light fluorescence study. Indian J Dent Res. 2013 Nov-Dec;24(6):681-9. doi: 10.4103/0970-9290.127610.
Gomez J, Pretty IA, Santarpia RP 3rd, Cantore B, Rege A, Petrou I, Ellwood RP. Quantitative light-induced fluorescence to measure enamel remineralization in vitro. Caries Res. 2014;48(3):223-7. doi: 10.1159/000354655. Epub 2014 Jan 29.
Other Identifiers
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thesis
Identifier Type: -
Identifier Source: org_study_id
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