Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-27

Study Completion Date

2020-12-31

Brief Summary

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The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis patients.

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Detailed Description

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Thirty (30) intrabony defects of 18 patients (9 males, 9 females) were randomly divided in two treatment groups: test (n = 15) and control (n = 15). The intrabony defects were filled with A-PRF+ (n=15) in the test group, respectively with EMD in the control group, and fixed with sutures to ensure wound closure and stability.

Conditions

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Periodontal Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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A-PRF

Advanced Platelet-Rich Fibrin

Group Type ACTIVE_COMPARATOR

A-PRF/EMD

Intervention Type PROCEDURE

Comparing healing effect of an autologous and a xenogenic product

EMD

Enamel Matrix Derivatives

Group Type ACTIVE_COMPARATOR

A-PRF/EMD

Intervention Type PROCEDURE

Comparing healing effect of an autologous and a xenogenic product

Interventions

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A-PRF/EMD

Comparing healing effect of an autologous and a xenogenic product

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* no systemic diseases that could influence the outcome of the therapy, a good level of oral hygiene, he presence of a 2-, 3-, or combined 2-3-wall intrabony defect with a defect angle of 20-40 (+/- 5) degrees, with a minimum PPD of 6 mm and intrabony component of a minimum 4 mm as detected on radiographs, no smoking