Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

NCT ID: NCT05001035

Last Updated: 2021-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-01

Study Completion Date

2021-09-20

Brief Summary

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This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

Detailed Description

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Conditions

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White Spot Lesion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Split mouth technique
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Zinc carbonated hydroxy apatite

Toothpaste to be added on white spot lesions in dental enamel

Group Type EXPERIMENTAL

Time of assessment

Intervention Type OTHER

Immediate and after one month and after two months

Bioactive glass

Toothpaste to be added on white spot lesions in dental enamel

Group Type EXPERIMENTAL

Time of assessment

Intervention Type OTHER

Immediate and after one month and after two months

Poly amido amine

Resinous material to be painted on white spot lesions in dental enamel

Group Type EXPERIMENTAL

Time of assessment

Intervention Type OTHER

Immediate and after one month and after two months

Control

No material to be added

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Time of assessment

Immediate and after one month and after two months

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Total of 21 patients enrolled in this study will be selected having at least 4 teeth (one on each quadrant) which will be extracted for orthodontic treatment.
* These patients will be selected according to age groups between 15-25 years old
* good oral hygiene
* free of destroying habits for dental tissues

Exclusion Criteria

* Bruxism
* soft drinks consumption
* acid regurgitation, etc.).
* Selected teeth having any cracks, malformations, dysplasia or caries.
Minimum Eligible Age

15 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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Eptesam Atef

Dental specialist at benha teaching hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of dental medicine for girls branch of Alazhar University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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OPDEN-107-1-G

Identifier Type: OTHER

Identifier Source: secondary_id

OP-P-018-001

Identifier Type: -

Identifier Source: org_study_id

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