Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
21 participants
INTERVENTIONAL
2019-06-12
2020-03-06
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Beetroot Juice Low
Subjects will consume beetroot juice containing 250mg inorganic nitrate and 20mg nitrite dissolved in 120ml bottled water. Peripheral chemoreflex sensitivity as well as common carotid artery blood flow will be assessed before and after supplementation.
Pre-beetroot juice supplementation
Before administering beetroot juice to subjects.
Post-beetroot juice supplementation
After administering beetroot juice to subjects.
Beetroot Juice High
Subjects will consume beetroot juice containing 500mg inorganic nitrate and 40mg nitrite dissolved in 120ml bottled water. Peripheral chemoreflex sensitivity as well as common carotid artery blood flow will be assessed before and after supplementation.
Pre-beetroot juice supplementation
Before administering beetroot juice to subjects.
Post-beetroot juice supplementation
After administering beetroot juice to subjects.
Beetroot Juice Placebo
Subjects will consume beetroot juice devoid of inorganic nitrate and nitrite dissolved in 120ml bottled water. Peripheral chemoreflex sensitivity as well as common carotid artery blood flow will be assessed before and after supplementation.
Pre-beetroot juice supplementation
Before administering beetroot juice to subjects.
Post-beetroot juice supplementation
After administering beetroot juice to subjects.
Interventions
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Pre-beetroot juice supplementation
Before administering beetroot juice to subjects.
Post-beetroot juice supplementation
After administering beetroot juice to subjects.
Eligibility Criteria
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Inclusion Criteria
* Control group: healthy individuals
Exclusion Criteria
* Diagnosis of diabetes
* Diagnosis of any autonomic disorders
* Diagnosis of kidney disease
* Diagnosis of central sleep apnea
* Regular physical activity exceeding 30 minutes 3 days/week
* A body mass index ≥40 kg/m2
* Current or former use of a continuous positive airway pressure machine
* Current tobacco use
* Currently prescribed hormone replacement therapy
30 Years
70 Years
ALL
Yes
Sponsors
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University of Iowa
OTHER
Responsible Party
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Darren P Casey
Assistant Professor
Principal Investigators
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Darren P Casey, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Iowa
Locations
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Medical Education Building
Iowa City, Iowa, United States
Countries
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Other Identifiers
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201812786
Identifier Type: -
Identifier Source: org_study_id
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