rTMS for Orthopaedic Trauma Patients

NCT ID: NCT03924024

Last Updated: 2022-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-01

Study Completion Date

2021-02-01

Brief Summary

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This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for orthopaedic trauma patients. In this open label study, all participants will receive accelerated theta-burst stimulation. This study will examine whether symptoms of psychiatric distress and opioid use in orthopaedic trauma patients can be mitigated with rTMS to improve post-injury recovery.

Detailed Description

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A large percentage of orthopaedic trauma patients suffer from psychiatric distress and chronic pain related to their injury and underlying psychosocial factors; this predicts poor post-injury recovery.

Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulation technique used to stimulate areas of the brain that may modulate symptoms of pain, depression, and post-traumatic stress. The FDA-approved rTMS protocol for treatment is 10Hz stimulation for 40 minutes over the left dorsolateral prefrontal cortex (L-DLPFC) for the treatment of depression. This methodology has been very successful in real world situations, however poses some limitations, including the duration of the treatment session (approximately 40 minutes per treatment session). Recently, researchers have aggressively pursued modifying the treatment parameters to reduce treatment times with some preliminary success. This study will use modified parameters to create a more rapid form of treatment and look at outcome changes in pain and depression, commonly seen in orthopaedic trauma patients.

Conditions

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Orthopaedic Trauma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Accelerated intermittent theta burst treatment

All participants will receive accelerated intermittent theta-burst stimulation.

Group Type EXPERIMENTAL

Accelerated intermittent theta burst treatment

Intervention Type DEVICE

All participants will receive accelerated intermittent theta-burst stimulation to the left DLPFC. Stimulation intensity will be standardized to 80% of resting motor threshold.

Stimulation will be delivered to L-DLPFC using the Brainsway stimulator.

Interventions

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Accelerated intermittent theta burst treatment

All participants will receive accelerated intermittent theta-burst stimulation to the left DLPFC. Stimulation intensity will be standardized to 80% of resting motor threshold.

Stimulation will be delivered to L-DLPFC using the Brainsway stimulator.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male or female, 18 to 65 years of age.
* Able to provide informed consent.
* Present to Stanford Emergency Department as a trauma with a major operative lower extremity injury
* Glasgow coma scale of 15 within 24 hours after admission or extubation
* Negative urinary toxicology screen for illicit substances;
* Negative pregnancy test if female and less then 60 y/o;
* No suspicion for a head injury and/or negative head CT scan for intracranial hemorrhage or injury based on standard of care
* No history of seizure disorder or other neurological disorders.
* All patients included must screen positive for PHQ-9 score \>4 (positive symptoms of depression) and CES-T score \<36 (poor coping self-efficacy).

Exclusion Criteria

* Incarceration,
* Pregnant females,
* Prior psychotic disorder,
* Current use of anti-depressant or anti-psychotic medications,
* Prior-admission opioid use within 30 days (patients will be screened for recent prescription opioid use using the CURES report),
* Heavy alcohol use,
* Lesional neurological disorder or brain implant or intracranial ferromagnetic material,
* Seizure disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Nolan R

Assistant Professor, Director of Interventional Psychiatry Clinical Research, Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nolan Williams, MD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Department of Orthopaedic Surgery, Stanford Hospital

Palo Alto, California, United States

Site Status

Countries

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United States

References

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Reference Type BACKGROUND
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Jelic MB, Milanovic SD, Filipovic SR. Differential effects of facilitatory and inhibitory theta burst stimulation of the primary motor cortex on motor learning. Clin Neurophysiol. 2015 May;126(5):1016-23. doi: 10.1016/j.clinph.2014.09.003. Epub 2014 Sep 16.

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Chung SW, Hoy KE, Fitzgerald PB. Theta-burst stimulation: a new form of TMS treatment for depression? Depress Anxiety. 2015 Mar;32(3):182-92. doi: 10.1002/da.22335. Epub 2014 Nov 28.

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Plewnia C, Pasqualetti P, Grosse S, Schlipf S, Wasserka B, Zwissler B, Fallgatter A. Treatment of major depression with bilateral theta burst stimulation: a randomized controlled pilot trial. J Affect Disord. 2014 Mar;156:219-23. doi: 10.1016/j.jad.2013.12.025. Epub 2013 Dec 28.

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PMID: 24411682 (View on PubMed)

Prasser J, Schecklmann M, Poeppl TB, Frank E, Kreuzer PM, Hajak G, Rupprecht R, Landgrebe M, Langguth B. Bilateral prefrontal rTMS and theta burst TMS as an add-on treatment for depression: a randomized placebo controlled trial. World J Biol Psychiatry. 2015 Jan;16(1):57-65. doi: 10.3109/15622975.2014.964768. Epub 2014 Nov 28.

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Daskalakis ZJ. Theta-burst transcranial magnetic stimulation in depression: when less may be more. Brain. 2014 Jul;137(Pt 7):1860-2. doi: 10.1093/brain/awu123. Epub 2014 May 15. No abstract available.

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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8. doi: 10.1073/pnas.0135058100. Epub 2002 Dec 27.

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Greicius MD, Supekar K, Menon V, Dougherty RF. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex. 2009 Jan;19(1):72-8. doi: 10.1093/cercor/bhn059. Epub 2008 Apr 9.

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Hanlon CA, Dowdle LT, Austelle CW, DeVries W, Mithoefer O, Badran BW, George MS. What goes up, can come down: Novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals. Brain Res. 2015 Dec 2;1628(Pt A):199-209. doi: 10.1016/j.brainres.2015.02.053. Epub 2015 Mar 11.

Reference Type BACKGROUND
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Taylor JJ, Borckardt JJ, George MS. Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia. Pain. 2012 Jun;153(6):1219-1225. doi: 10.1016/j.pain.2012.02.030. Epub 2012 Mar 22.

Reference Type BACKGROUND
PMID: 22444187 (View on PubMed)

Borckardt JJ, Weinstein M, Reeves ST, Kozel FA, Nahas Z, Smith AR, Byrne TK, Morgan K, George MS. Postoperative left prefrontal repetitive transcranial magnetic stimulation reduces patient-controlled analgesia use. Anesthesiology. 2006 Sep;105(3):557-62. doi: 10.1097/00000542-200609000-00020.

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Borckardt JJ, Smith AR, Hutcheson K, Johnson K, Nahas Z, Anderson B, Schneider MB, Reeves ST, George MS. Reducing pain and unpleasantness during repetitive transcranial magnetic stimulation. J ECT. 2006 Dec;22(4):259-64. doi: 10.1097/01.yct.0000244248.40662.9a.

Reference Type BACKGROUND
PMID: 17143157 (View on PubMed)

Borckardt JJ, Smith AR, Reeves ST, Weinstein M, Kozel FA, Nahas Z, Shelley N, Branham RK, Thomas KJ, George MS. Fifteen minutes of left prefrontal repetitive transcranial magnetic stimulation acutely increases thermal pain thresholds in healthy adults. Pain Res Manag. 2007 Winter;12(4):287-90. doi: 10.1155/2007/741897.

Reference Type BACKGROUND
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Borckardt JJ, Smith AR, Reeves ST, Madan A, Shelley N, Branham R, Nahas Z, George MS. A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain. Pain Med. 2009 Jul-Aug;10(5):840-9. doi: 10.1111/j.1526-4637.2009.00657.x. Epub 2009 Jul 6.

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Borckardt JJ, Reeves ST, Weinstein M, Smith AR, Shelley N, Kozel FA, Nahas Z, Byrne KT, Morgan K, George MS. Significant analgesic effects of one session of postoperative left prefrontal cortex repetitive transcranial magnetic stimulation: a replication study. Brain Stimul. 2008 Apr;1(2):122-7. doi: 10.1016/j.brs.2008.04.002.

Reference Type BACKGROUND
PMID: 19759838 (View on PubMed)

Other Identifiers

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49006

Identifier Type: -

Identifier Source: org_study_id

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