Post Approval Study of the Eversense® Continuous Glucose Monitoring

NCT ID: NCT03908125

Last Updated: 2025-06-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

273 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-19

Study Completion Date

2024-02-01

Brief Summary

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A Post Approval Study to Evaluate the Long-term Safety and Effectiveness of the Eversense® Continuous Glucose Monitoring (CGM) System over repeat insertion and removal cycles and to demonstrate the long-term safety of the Eversense® CGM System

Detailed Description

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The purpose of this post-approval study (PAS) is to provide long-term safety and effectiveness of the Eversense CGM System (PMA Application P160048) in the post-market setting. In the premarket setting, the PRECISE II and PRECISION studies demonstrated safety and accuracy of the CGM system in estimating blood glucose levels compared to reference blood glucose analyzer levels to 90 days.

The PROMISE study demonstrated safety and accuracy of the CGM system up to 180 days. This PAS study will provide safety and effectiveness data up to 27 months of repeated use.

Conditions

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Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Continuous Glucose Monitoring Device

Commercial Continuous Glucose Monitoring Device

Group Type OTHER

Eversense® CGM System

Intervention Type DEVICE

Continuous Glucose monitoring device

Interventions

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Eversense® CGM System

Continuous Glucose monitoring device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subject has diabetes
2. Subject is greater than 18 years of age

Exclusion Criteria

1. Subject is critically ill or hospitalized
2. Subject has a known contraindication to dexamethasone or dexamethasone acetate
3. Subjects requiring intravenous mannitol or mannitol irrigation solutions
4. Female subjects who are pregnant, planning on becoming pregnant or nursing
5. Subjects on hybrid closed loop systems or closed loop systems
6. Subjects on other CGM systems
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Senseonics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kathleen Davis

Role: STUDY_DIRECTOR

Senseonics, Inc.

Locations

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Hoag Memorial Hospital Presbyterian/Mary Dick Allen Diabetes Center

Newport Beach, California, United States

Site Status

Denver Endocrinology, Diabetes & Thyroid Center

Englewood, Colorado, United States

Site Status

The Center for Diabetes and Endocrine Care

Fort Lauderdale, Florida, United States

Site Status

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Site Status

MODEL Clinical research

Baltimore, Maryland, United States

Site Status

Metro Detroit Endocrinology Center

Dearborn, Michigan, United States

Site Status

Diabetes and Endocrinology Specialists, Inc.

Chesterfield, Missouri, United States

Site Status

Albany Medical College

Albany, New York, United States

Site Status

Physicians East

Greenville, North Carolina, United States

Site Status

PMG Research of Wilmington, LLC

Wilmington, North Carolina, United States

Site Status

Diabetes & Endocrinology Consultants of Pennsylvania, LLC

Feasterville, Pennsylvania, United States

Site Status

AM Diabetes & Endocrinology

Bartlett, Tennessee, United States

Site Status

Texas Diabetes and Endocrinology

Austin, Texas, United States

Site Status

Clinical Research Solution, LLC

Cypress, Texas, United States

Site Status

Javara, Inc

Houston, Texas, United States

Site Status

Diabetes and Glandular Disease Clinic

San Antonio, Texas, United States

Site Status

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CTP-0034

Identifier Type: -

Identifier Source: org_study_id

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