The 3q25 rs2305619 Polymorphism Associates With Microvascular Obstruction in STEMI

NCT ID: NCT03907722

Last Updated: 2019-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

217 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2018-09-03

Brief Summary

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The investigators enrolled 217 patients with acute STEMI undergoing primary PCI. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit.

Detailed Description

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The investigators enrolled 217 patients with acute STEMI undergoing primary PCI in a tertiary care academic cardiovascular center. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit. The primary outcome of the study was the incidence of coronary microvascular obstruction defined as thrombolysis in myocardial infarction (TIMI) grade \<3 flow after primary PCI or TIMI grade 3 flow with myocardial blush grade 0 or 1. Patients were grouped based on the genotypic variants (AA, AG and GG). The primary outcome was compared among the three variants, as well as the PTX3 concentration and 30-day mortality.

Conditions

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STEMI Microvascular Coronary Artery Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Genotypic variants

AA, AG and GG genotype

Long pentraxin 3

Intervention Type OTHER

Primary PCI

Interventions

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Long pentraxin 3

Primary PCI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with acute STEMI with symptom onset \<12 h and treated by primary PCI

Exclusion Criteria

* STEMI patients who received fibrinolytic therapy
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Indonesian Cardiovascular Research Center

OTHER

Sponsor Role lead

Responsible Party

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Surya Dharma

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Surya Dharma, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Indonesian Cardiovascular Center

Locations

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Indonesian Cardiovascular Research Center

Jakarta, DKI Jakarta, Indonesia

Site Status

Countries

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Indonesia

Other Identifiers

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IndonesianCRC2

Identifier Type: -

Identifier Source: org_study_id

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